METHOD OF PRODUCING SILODOSIN SYNTHESIS INTERMEDIATE AND METHOD OF PRODUCING SILODOSIN USING THE SAME

To provide a method of producing a silodosin synthesis intermediate and a method of producing silodosin using the same, which increase the price competitive power, reduce hazardous materials in production processes, facilitate efficient mass production, and can provide optically pure silodosin with high purity.SOLUTION: The methods of producing the silodosin synthesis intermediate and silodosin include synthesizing 3-(5-(2-((tert-butoxycarbonyl)amino)propyl)-7-cyanoindolin-1-yl)propyl benzoate as an intermediate, mixing it with an organic acid having optical activity, and performing optical resolution.SELECTED DRAWING: None 【課題】価格競争力を高め、製造過程の危険要素を減らし、効率的な大量生産を容易にし、光学的に純粋な高純度のシロドシンを得ることができるシロドシン合成用中間体の製造方法及びシロドシンの製造方法の提供。【解決手段】３−（５−（２−（（ｔｅｒｔ−ブトキシカルボニル）アミノ）プロピル）−７−シアノインドリン−１−イル）プロピルベンゾエートを中間体として合成し、光学活性のある有機酸と混合して、光学分割する段階を含む、シロドシン合成用中間体及びシロドシンのの製造方法。【選択図】なし