COMPOSITIONS AND METHODS RELATING TO OCCLUSIVE POLYMER HYDROGEL

To provide a composition for a long-term reversible male contraceptive by forming a hydrogel tissue bridge that can create an occlusion within the vas deferens.SOLUTION: Methods for synthesis of hydrogel tissue bridges comprise dissolving a styrene maleic acid-based polymer in dimethyl sulfoxide and...

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Hauptverfasser:	DAVID TEMPLER, DONALD P WALLER, ANTONINA NIKITENKO, GARY GAMERMAN, ELAINE LISSNER, JEFFERY DEPINTO, DAVID BOLICK
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BANDAGES, DRESSINGS OR ABSORBENT PADS CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC MACROMOLECULAR COMPOUNDS ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROSTHESES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP TREATMENT OR PROTECTION OF EYES OR EARS
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Beschreibung
Zusammenfassung:	To provide a composition for a long-term reversible male contraceptive by forming a hydrogel tissue bridge that can create an occlusion within the vas deferens.SOLUTION: Methods for synthesis of hydrogel tissue bridges comprise dissolving a styrene maleic acid-based polymer in dimethyl sulfoxide and injecting it into the vasa deferentia of male subjects thereby creating a hydrogel tissue bridge. The hydrogel tissue bridge is disrupted by injecting the lumen of the vas deferens with a basic buffer solution.SELECTED DRAWING: None 【課題】長期的可逆的男性避妊の為、輸精管内に閉塞状態を作ることができるヒドロゲル組織ブリッジを形成する組成物の提供。【解決手段】ヒドロゲル組織ブリッジの合成のためにスチレンマレイン酸系ポリマーをジメチルスルホキシドに溶解させて男性被検体の輸精管に注射し、ヒドロゲル組織ブリッジを作る方法。また、このヒドロゲル組織ブリッジは、輸精管の管腔に塩基性緩衝液を注射することにより破壊することができる方法。【選択図】なし