PROTEIN STABILIZER

To provide a high-performance protein stabilizer by chemical synthesis, useful for maintaining activity of an antibody and the like used as a clinical diagnostic agent.SOLUTION: A protein stabilizer contains a hydrophilic repeating unit composed of a repeating unit represented by the following formu...

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Bibliographische Detailangaben
Hauptverfasser:	KITAMURA YUKI, MIYAJI MASAAKI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS METALLURGY ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS PEPTIDES THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	To provide a high-performance protein stabilizer by chemical synthesis, useful for maintaining activity of an antibody and the like used as a clinical diagnostic agent.SOLUTION: A protein stabilizer contains a hydrophilic repeating unit composed of a repeating unit represented by the following formula or the like, and a copolymer having a hydrophobic repeating unit. [In a formula (1), Ris a hydrogen atom or a methyl group, Rand Rindependently represent a hydrogen atom, or a C1-6 alkyl group or hydroxyalkyl group].SELECTED DRAWING: None 【課題】臨床診断薬として使用される抗体などの活性を維持するために有用な、化学合成による高性能のタンパク安定化剤の提供。【解決手段】下記式で表される繰り返し単位などからなる親水性繰り返し単位と、疎水性繰り返し単位を有する共重合体を含有する、タンパク安定化剤。〔式（１）中、Ｒ1は、水素原子又はメチル基を示し、Ｒ２及びＲ３は、それぞれ独立して、水素原子、または炭素数１〜６のアルキル基またはヒドロキシアルキル基を示す。〕【選択図】なし