PRODUCTS COMPRISING EXTRACELLULAR MATRIX TISSUE MATERIAL AND OSTEOGENIC PROTEIN

To provide improved or alternative osteogenic compositions that can make highly beneficial use of an osteogenic factor, and methods of use and preparation thereof.SOLUTION: Osteogenic compositions include an extracellular matrix tissue material and bone morphogenic protein, preferably BMP-2. The com...

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Hauptverfasser:	STEVEN CHARLEBOIS, NEAL E FEARNOT, SHELLEY L WALLACE, AMANDA F TAYLOR, CHRISTINE M STEINHART
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY DISINFECTION, STERILISATION, OR DEODORISATION OF AIR ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL MICROBIOLOGY MUTATION OR GENETIC ENGINEERING SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide improved or alternative osteogenic compositions that can make highly beneficial use of an osteogenic factor, and methods of use and preparation thereof.SOLUTION: Osteogenic compositions include an extracellular matrix tissue material and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparin sulfate) remaining in the decellularized extracellular matrix tissue material. The compositions and related methods can be used in treatment of diseased or damaged bone tissue.SELECTED DRAWING: Figure 1 【課題】骨原性因子を有益に利用することができる、改善された骨原性組成物、あるいは代替組成物、ならびにそれらの使用と製造方法の提供。【解決手段】細胞外マトリックス組織物質および骨形成タンパク質、好ましくはＢＭＰ−２を含む骨原性組成物。該組成物は、ＢＭＰを有用に使用し、比較的低い投与量で使用されて、脱細胞された細胞外マトリックス組織材料中に保持される生来の成分（ヘパリンおよび／またはヘパリン硫酸のような生来の硫酸化グリコサミノグリカン類）に結合することができる。該組成物および関連する方法は、病気または損傷された骨組織の治療に使用される。【選択図】図１