PREVENTION OF AND RECOVERY FROM DRUG-INDUCED OTOTOXICITY
To provide methods for preventing and/or reducing the severity of drug induced ototoxicity.SOLUTION: There is provided a pharmaceutical composition used for preventing ototoxicity induced by a drug when administered prior to the onset of therapy using the drug. The pharmaceutical composition contain...
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| Sprache: | eng ; jpn |
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| Zusammenfassung: | To provide methods for preventing and/or reducing the severity of drug induced ototoxicity.SOLUTION: There is provided a pharmaceutical composition used for preventing ototoxicity induced by a drug when administered prior to the onset of therapy using the drug. The pharmaceutical composition contains 1-100 μm of an anti-apoptotic agent. The pharmaceutical composition provides sustained release of the anti-apoptotic agent into the ear for at least 5 days after the administration. The anti-apoptotic agent increases the survival of inner hair cells and the spiral ganglion.SELECTED DRAWING: Figure 9
【課題】薬物により誘発される耳毒性の重篤性を予防及び／又は減少する方法の提供。【解決手段】薬物を用いる治療の開始の前に投与されるときに、該薬物により誘発される耳毒性を予防するために使用される医薬組成物であって、該医薬組成物は、１−１００μｍの抗アポトーシス性薬剤を含み、該医薬組成物は、投与の後少なくとも５日間、耳の中への抗アポトーシス性薬剤の徐放を提供し、抗アポトーシス性薬剤は内有毛細胞および螺旋神経節の生存率を高めることを特徴とする、医薬組成物。【選択図】図９ |
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