METHOD OF REDUCING NEURONAL CELL DEATH WITH HALOALKYLAMINES

To provide pharmaceutical compositions and methods of treating traumatic brain injury (TBI), and pharmaceutical compositions and methods of treating a transient hypoxic and/or ischemic condition in the central nervous system.SOLUTION: The method comprises administering to a subject a therapeutically effective amount, specifically a dose of up to 40 mg, of phenoxybenzamine in a single dose within 24 hours, 16 hours or 8 hours after the onset of transient hypoxia and/or TBI, as an extended release formulation comprising a pharmaceutically acceptable carrier.SELECTED DRAWING: Figure 1 【課題】外傷性脳損傷（ＴＢＩ）を処置する医薬組成物及び方法、又は中枢神経系における一過性低酸素及び／又は虚血状態を処置する医薬組成物及び方法の提供。【解決手段】被験体に療法有効量、具体的には最大４０ｍｇの用量のフェノキシベンザミンを、一過性低酸素及び／又はＴＢＩの発生後２４時間以内、又は１６時間以内、或いは８時間以内に、医薬的に許容できるキャリヤーを含む持続放出配合物として、単回投与にて投与することを含む方法。【選択図】図１