MANUFACTURING METHOD OF NONAQUEOUS SKIN EXTERNAL COMPOSITION

To provide a manufacturing method of a nonaqueous skin external composition in which strongly hydrophobic and amphiphilic solid active ingredient is solubilized into oil phase.SOLUTION: A manufacturing method of the nonaqueous skin external composition melting or distributing strongly hydrophobic and amphiphilic solid active ingredient-surfactant complex in the oil phase comprises: a step of melting surfactant in oil phase to obtain surfactant solution; a step of mixing the obtained surfactant solution and the strongly hydrophobic and amphiphilic solid active ingredient to obtain suspension; and a step of standing the suspension to obtain transparent composition.EFFECT: Different from conventional S/O type formulating preparations, the manufacturing method can solubilize the strongly hydrophobic and amphiphilic solid active ingredient in the oil phase without emulsification and lyophilization process.SELECTED DRAWING: None 【課題】強親水性両親媒性固体有効成分を油相中に可溶化してなる非水系皮膚外用組成物の製造方法の提供。【解決手段】油相に界面活性剤を溶解させて界面活性剤溶液を得る工程と、得られた界面活性剤溶液に強親水性両親媒性固体有効成分を混合し、懸濁液を得る工程と、得られた懸濁液を静置して透明な組成物を得る工程とを含む、強親水性両親媒性固体有効成分−界面活性剤複合体が油相中に溶解または分散してなる非水系皮膚外用組成物の製造方法。【効果】前記方法によれば、従来のＳ／Ｏ型の製剤調製法と異なり、乳化および凍結乾燥プロセスを経ることなく、強親水性両親媒性固体有効成分を油相中に可溶化させることができる。【選択図】なし