METHODS AND SYSTEMS FOR FORMING BORONIC ACIDS AND INTERMEDIATES THEREOF

METHODS AND SYSTEMS FOR FORMING BORONIC ACIDS AND INTERMEDIATES THEREOF

To provide methods for efficiently forming boronic acids and intermediates thereof.SOLUTION: A method of forming a boronic acid comprises: reacting a 1-chloro-2-substituted-3-fluorobenzene with at least one alkyllithium to form a reaction mixture comprising a lithiated intermediate; and continuously...

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Bibliographische Detailangaben
Hauptverfasser: MARK V M EMONDS, CATHERINE A MENNING, D WAYNE BLAYLOCK
Format: Patent
Sprache:eng ; jpn
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:To provide methods for efficiently forming boronic acids and intermediates thereof.SOLUTION: A method of forming a boronic acid comprises: reacting a 1-chloro-2-substituted-3-fluorobenzene with at least one alkyllithium to form a reaction mixture comprising a lithiated intermediate; and continuously adding a borate to the reaction mixture to form a boronate. A system for forming the boronic acid comprises: a first and a second reactor, and a transfer tube for transferring a liquid.SELECTED DRAWING: None 【課題】高効率でボロン酸およびその中間体を生成させるための方法の提供。【解決手段】１−クロロ−２−置換−３−フルオロベンゼンを少なくとも１種のアルキルリチウムと反応させてリチウム化中間体を含む反応混合物を生成させるステップと、前記反応混合物にホウ酸エステルを連続的に添加してボロン酸エステルを生成させるステップとを含むボロン酸を生成させる方法。さらに、第１、第２の反応器、及び液体移送のための移送チューブを有する、前記ボロン酸を生成させるためのシステム。【選択図】なし