[6R]-MTHF, AN EFFECTIVE FOLATE ALTERNATIVE IN 5-FLUOROURACIL BASED CHEMOTHERAPY

To provide pharmaceutical compositions for treating human solid tumors such as cancer.SOLUTION: Disclosed herein is a pharmaceutical compositions for a) on Day 1, administering an IV bolus containing 10-1000 mg/m(BSA) of 5-FU (or an analog or prodrug thereof); then b) either simultaneously or after a period of from 10 min to 4 hours, administering one or more IV boluses, each containing 5-1000 mg/mof [6R]-5,10-methylenetetrahydrofolate; and then, d) on Day 2, administering one or more IV boluses each containing 10-1000 mg/m(BSA) of 5-FU (or an analog or prodrug thereof).SELECTED DRAWING: Figure 2 【課題】癌等のヒトの固形腫瘍の治療用医薬組成物。【解決手段】ａ）第１日目に、１０〜１０００ｍｇ／ｍ２（ＢＳＡ）の５−ＦＵ（又はその類似体もしくはプロドラッグ）を含むＩＶボーラスを投与し；その後同時に、又は１０分〜４時間後に、ｂ）１又は複数回のＩＶボーラス投与を行い、各ボーラスは５〜１０００ｍｇ／ｍ２の［６Ｒ］−５，１０−メチレンテトラヒドロ葉酸を含み；その後、ｄ）第２日目に、１０〜１０００ｍｇ／ｍ２（ＢＳＡ）の５−ＦＵ（又はその類似体もしくはプロドラッグ）を含む１又は複数回のＩＶボーラス投与を行うための医薬組成物。【選択図】図２