METHODS FOR TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND ANTI-GPC3 ANTIBODIES

To provide compositions and methods for treating cancer.SOLUTION: The method of the invention comprises administration of a PD-1 axis binding antagonist and an anti-GPC3 antibody. The composition of the invention comprises a pharmaceutical composition for treating cancer comprising a PD-1 axis bindi...

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Bibliographische Detailangaben
Hauptverfasser:	KATO ATSUHIKO, OTOMO TOSHIHIKO, KINOSHITA KYOKO, NARITA YOSHINORI, ENDO MIKA, ADACHI KENJI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide compositions and methods for treating cancer.SOLUTION: The method of the invention comprises administration of a PD-1 axis binding antagonist and an anti-GPC3 antibody. The composition of the invention comprises a pharmaceutical composition for treating cancer comprising a PD-1 axis binding antagonist and an anti-GPC3 antibody. Also disclosed herein is a pharmaceutical composition comprising an anti-GPC3 antibody as an effective ingredient for use in combination with a PC-1 axis antagonist for treating cancer. Also disclosed is a pharmaceutical composition comprising a PD-1 axis binding antagonist for use in combination with an anti-GPC3 antibody for treating cancer.SELECTED DRAWING: None 【課題】癌を治療するための組成物および方法の提供。【解決手段】ＰＤ−１系結合アンタゴニストおよび抗ＧＰＣ３抗体を投与することを含む方法。ＰＤ−１系結合アンタゴニストおよび抗ＧＰＣ３抗体を含む癌を治療するための医薬組成物を含む組成物。有効成分として抗ＧＰＣ３抗体を含む、癌を治療するためにＰＤ−１系結合アンタゴニストと組み合わせて使用されるべき医薬組成物および有効成分としてＰＤ−１系結合アンタゴニストを含む、癌を治療するために抗ＧＰＣ３抗体と組み合わせて使用されるべき医薬組成物。【選択図】なし