METHOD AND MEDICAMENT FOR INHIBITING EXPRESSION OF GIVEN GENE

To provide agents containing at least one double-stranded oligoribonucleotide (double-stranded RNA) designed to inhibit expression of a target gene.SOLUTION: One strand in the double-stranded RNA is at least in part complementary to a target gene. The target gene may be selected from the following g...

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Bibliographische Detailangaben
Hauptverfasser:	KREUTZER ROLAND, LIMMER STEPHAN
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide agents containing at least one double-stranded oligoribonucleotide (double-stranded RNA) designed to inhibit expression of a target gene.SOLUTION: One strand in the double-stranded RNA is at least in part complementary to a target gene. The target gene may be selected from the following group: an oncogene, a cytokine gene, an Id protein gene, a developmental gene, and a prion gene. The target gene may be expressed in pathogenic organisms (in particular, Plasmodium). The target gene may be part of a virus or viroid which is preferably pathogenic to humans.SELECTED DRAWING: None 【課題】本発明は、標的遺伝子の発現を抑制するように設計された少なくとも１の二本鎖オリゴリボヌクレオチド（二本鎖ＲＮＡ）を含む薬剤に関する。【解決手段】本発明によれば、その二本鎖ＲＮＡの１の鎖は、少なくとも一部が標的遺伝子に相補的である。標的遺伝子は下記の群から選択することができる：ガン遺伝子、サイトカイン遺伝子、Ｉｄ蛋白質遺伝子、発生遺伝子、プリオン遺伝子。標的遺伝子は、病原性生物（特に、プラスモディウム）において発現し得る。標的遺伝子はまた、好ましくはヒトに対して病原性であるウイルスまたはウイロイドの一部であり得る。【選択図】なし