MONOCLONAL ANTIBODIES AND ASSAY KITS

To provide novel monoclonal antibodies against MERS-CoV.SOLUTION: The invention provides a monoclonal antibody against MERS coronavirus that specifically binds to MERS corona virus and neutralizes the viral activity. In certain embodiments, the monoclonal antibody has an amino acid sequence in which...

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Bibliographische Detailangaben
Hauptverfasser:	SHIRATO NORIYA, FUKUSHI HIDEETSU, ONISHI KAZUO, YOSHIKAWA NAOKO, NAGATA NORIYO, MATSUYAMA SHUTOKU
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	To provide novel monoclonal antibodies against MERS-CoV.SOLUTION: The invention provides a monoclonal antibody against MERS coronavirus that specifically binds to MERS corona virus and neutralizes the viral activity. In certain embodiments, the monoclonal antibody has an amino acid sequence in which the heavy chain variable region has a specific sequence, and the light chain variable region has another specific sequence. The invention also provides an assay kit for determining the presence of neutralizing antibodies that neutralize the viral activity of MERS coronavirus in a test sample by using the monoclonal antibody.SELECTED DRAWING: Figure 1 【課題】MERS-CoVに対する新規なモノクローナル抗体を提供する。【解決手段】MERSコロナウイルスに特異的に結合し、そのウイルス活性を中和するMERSコロナウイルスに対するモノクローナル抗体。重鎖可変部領域が特定な配列からなるアミノ酸配列であり、軽鎖可変部領域が別の特定な配列からなるアミノ酸配列であるモノクロナール抗体。このモノクローナル抗体を使用して、試験サンプル中においてMERSコロナウイルスのウイルス活性を中和する中和抗体の存在を測定するための測定キット。【選択図】図１