AGENT FOR IMPROVING SKIN RETENTION AND ANTIFUNGAL CARE PREPARATION CONTAINING THE SAME

PROBLEM TO BE SOLVED: To provide an agent for improving skin retention and an antifungal care preparation containing the same.SOLUTION: An agent for improving the skin retention of an antifungal agent contains a lipid peptide compound comprising at least one of a compound represented by the following formula (1) or its pharmaceutically acceptable salt, and a fatty acid (where Ris an aliphatic group having 9 to 23 carbon atoms, Ris a hydrogen atom, or an alkyl group having 1 to 4 carbon atoms, which can have a branch having 1 or 2 carbon atoms, Ris a -(CH)-X group, n is the number of 1 to 4, X is an amino group, a guanidino group, a -CONHgroup, or a condensed heterocycle comprising a 5 membered ring or a 6 membered ring, or a 5 membered ring and a 6 membered ring, which can have 1 to 3 nitrogen atoms).SELECTED DRAWING: None 【課題】皮膚貯留性改善剤及びこれを含む抗真菌外用製剤を提供する。【解決手段】 下記式（１）で表される化合物又はその薬学的に使用可能な塩のうちの少なくとも一種からなる脂質ペプチド型化合物と脂肪酸とを含有する、抗真菌薬の皮膚貯留性改善剤。【化１】（式中、Ｒ1は炭素原子数９乃至２３の脂肪族基を表し、Ｒ2は水素原子、又は炭素原子数１若しくは２の分枝鎖を有し得る炭素原子数１乃至４のアルキル基を表し、Ｒ3は−（ＣＨ2）n−Ｘ基を表し、ｎは１乃至４の数を表し、Ｘはアミノ基、グアニジノ基、−ＣＯＮＨ2基、又は窒素原子を１乃至３個有し得る５員環若しくは６員環又は５員環と６員環から構成される縮合複素環を表す。）【選択図】なし