SEQUESTRANTS OF ADVANCED GLYCATION END PRODUCT (AGE) PRECURSORS

PROBLEM TO BE SOLVED: To provide drugs for treating conditions characterized by formation and accumulation of the advanced glycation end product (AGE).SOLUTION: A compound represented by general formula (I) is used. In the formula (I), n and o are each 0, 1 or 2; x is an integer from 2 to 25000; R,...

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Bibliographische Detailangaben
Hauptverfasser: MILLER ROBER J, MAGNUS BESEV, STEPHEN RANDALL HOLMES-FARLEY, ANDREW T PAPOULIS, PRADEEP DHAL
Format: Patent
Sprache:eng ; jpn
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide drugs for treating conditions characterized by formation and accumulation of the advanced glycation end product (AGE).SOLUTION: A compound represented by general formula (I) is used. In the formula (I), n and o are each 0, 1 or 2; x is an integer from 2 to 25000; R, R, Rand Rare each independently a polymer, -R-polymer, or the like; and Rand Rare each independently H, alkyl, heteroalkyl, or the like.SELECTED DRAWING: None 【課題】終末糖化産物(AGE)の形成、及び蓄積によることを特徴とする状況の治療のための薬剤の提供。【解決手段】一般式(I)で表される化合物の使用。式(I)中、n及びoは、0、1、又は2であり;xは、2から25000の整数であり;R1、R2、R3及びR4は、それぞれ独立に、ポリマー、−Rx−ポリマー等であり;R5及びR6は、それぞれ独立に、H、アルキル、ヘテロアルキル等である。【選択図】なし