DIAGNOSTIC MARKER FOR CEREBRAL INFARCTION

PROBLEM TO BE SOLVED: To provide a diagnostic marker that allows for appropriately diagnosing cerebral infarction.SOLUTION: A diagnostic marker for cerebral infarction contains at least one of; a peptide having an amino acid sequence represented by the SEQ ID No.171; a peptide having an amino acid s...

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Hauptverfasser: HIWASA SHIGEKI, GOTO KENICHIRO, MATSUMURA RYUTARO, SUGIYAMA TAKAO
Format: Patent
Sprache:eng ; jpn
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a diagnostic marker that allows for appropriately diagnosing cerebral infarction.SOLUTION: A diagnostic marker for cerebral infarction contains at least one of; a peptide having an amino acid sequence represented by the SEQ ID No.171; a peptide having an amino acid sequence represented by the SEQ ID No.113; a peptide having an amino acid sequence represented by the SEQ ID No.79; a peptide having an amino acid sequence represented by the SEQ ID No.57; and a peptide having an amino acid sequence represented by the SEQ ID No.63. Screening was conducted by a proto array method using serum of SLE patients to identify a plurality of proteins reacting positively with the serum as an antigen protein, thereby completing the present invention.SELECTED DRAWING: None 【課題】脳梗塞の診断を適切に行うことができる診断マーカーを提供する。【解決手段】配列番号171に示すアミノ酸配列からなるペプチド、配列番号113に示すアミノ酸配列からなるペプチド、配列番号79に示すアミノ酸配列からなるペプチド、配列番号57に示すアミノ酸配列からなるペプチド、及び、配列番号63に示すアミノ酸配列からなるペプチドの少なくとも何れか1つを含むことを特徴とする。SLE患者血清を用いてプロトアレイ法によるスクリーニングを行い、該血清と陽性反応を示す複数のタンパク質を抗原タンパク質として同定して、本発明を完成させるに至った。【選択図】なし