THERMOFORMED, TAMPER-RESISTANT PHARMACEUTICAL DOSAGE FORM CONTAINING ZINC

PROBLEM TO BE SOLVED: To provide pharmaceutical dosage forms to prevent the tamper of pharmacologically active ingredients such as opioids which have a potential of being abused.SOLUTION: The invention relates to a thermoformed, tamper-resistant pharmaceutical dosage form comprising a) a pharmacolog...

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Bibliographische Detailangaben
Hauptverfasser:	LUTZ BARNSCHEID, ANJA GEISSLER, JANA PAETZ, ERIC GALIA, SEBASTIAN SCHWIER, JULIA BARONSKY-PROBST
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide pharmaceutical dosage forms to prevent the tamper of pharmacologically active ingredients such as opioids which have a potential of being abused.SOLUTION: The invention relates to a thermoformed, tamper-resistant pharmaceutical dosage form comprising a) a pharmacologically active ingredient; b) a polyalkylene oxide having a weight average molecular weight of more than 200,000 g/mol; and c) a zinc component, wherein the content of said zinc component is at least 1 ppm, at most 10,000 ppm, relative to the total weight of the pharmaceutical dosage form.SELECTED DRAWING: None 【課題】乱用される可能性があるオピオイド等の医薬有効成分の不正使用を防止する医薬製剤の提供。【解決手段】ａ）医薬有効成分と、ｂ）２００，０００ｇ／ｍｏｌを超える重量平均分子量を有するポリアルキレンオキシドと、ｃ）亜鉛成分とを含み、前記亜鉛成分の含有量が、医薬製剤の総重量に対して少なくとも１ｐｐｍであり、最大でも１０，０００ｐｐｍである、熱成形された不正使用防止医薬製剤。【選択図】なし