NOVEL BENZIMIDAZOLE DERIVATIVE AND MEDICAL APPLICATION THEREOF
PROBLEM TO BE SOLVED: To provide a therapeutic agent for diseases to which Nav1.7 relates, especially neuropathic pain, nociceptive pain, inflammatory pain, small diameter fibrous neuropathy, erythromelalgia, paroxysmal pain, dysuria or multiple sclerosis or the like.SOLUTION: There is provided a co...
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| creator | ADACHI KEIJI IWAMOTO KOHEI SAWAYAMA YUSUKE KIYOSHIGE SAORI YAMAI YUSUKE |
| description | PROBLEM TO BE SOLVED: To provide a therapeutic agent for diseases to which Nav1.7 relates, especially neuropathic pain, nociceptive pain, inflammatory pain, small diameter fibrous neuropathy, erythromelalgia, paroxysmal pain, dysuria or multiple sclerosis or the like.SOLUTION: There is provided a compound represented by the formula (1), where Rto Rare H, cyano, Calkyl or the like, Rand Rare H, Calkyl, Ccycloalkyl, 3- to 7-membered heterocycle or the like, L is CRR, Rand Rare H, hydroxyl group, Calkyl or the like and m is 1 to 3.SELECTED DRAWING: None
【課題】Ｎａｖ１．７が関与する疾患、具体的には神経障害性疼痛、侵害受容性疼痛、炎症性疼痛、小径線維ニューロパチー、肢端紅痛症、発作性激痛症、排尿障害または多発性硬化症等の治療薬の提供。【解決手段】式（１）で表される化合物。[Ｒ１a〜Ｒ１ｄはＨ、シアノ、Ｃ１−４アルキル等；Ｒ２及びＲ３Ｈ、Ｃ１−６アルキル、Ｃ３−１０シクロアルキル、３〜７員の複素環等；ＬはＣＲ４Ｒ５；Ｒ４及びＲ５はＨ、水酸基、Ｃ１−４アルキル等；ｍは１〜３]【選択図】なし |
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【課題】Ｎａｖ１．７が関与する疾患、具体的には神経障害性疼痛、侵害受容性疼痛、炎症性疼痛、小径線維ニューロパチー、肢端紅痛症、発作性激痛症、排尿障害または多発性硬化症等の治療薬の提供。【解決手段】式（１）で表される化合物。[Ｒ１a〜Ｒ１ｄはＨ、シアノ、Ｃ１−４アルキル等；Ｒ２及びＲ３Ｈ、Ｃ１−６アルキル、Ｃ３−１０シクロアルキル、３〜７員の複素環等；ＬはＣＲ４Ｒ５；Ｒ４及びＲ５はＨ、水酸基、Ｃ１−４アルキル等；ｍは１〜３]【選択図】なし</description><language>eng ; jpn</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180405&DB=EPODOC&CC=JP&NR=2018052817A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76302</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180405&DB=EPODOC&CC=JP&NR=2018052817A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ADACHI KEIJI</creatorcontrib><creatorcontrib>IWAMOTO KOHEI</creatorcontrib><creatorcontrib>SAWAYAMA YUSUKE</creatorcontrib><creatorcontrib>KIYOSHIGE SAORI</creatorcontrib><creatorcontrib>YAMAI YUSUKE</creatorcontrib><title>NOVEL BENZIMIDAZOLE DERIVATIVE AND MEDICAL APPLICATION THEREOF</title><description>PROBLEM TO BE SOLVED: To provide a therapeutic agent for diseases to which Nav1.7 relates, especially neuropathic pain, nociceptive pain, inflammatory pain, small diameter fibrous neuropathy, erythromelalgia, paroxysmal pain, dysuria or multiple sclerosis or the like.SOLUTION: There is provided a compound represented by the formula (1), where Rto Rare H, cyano, Calkyl or the like, Rand Rare H, Calkyl, Ccycloalkyl, 3- to 7-membered heterocycle or the like, L is CRR, Rand Rare H, hydroxyl group, Calkyl or the like and m is 1 to 3.SELECTED DRAWING: None
【課題】Ｎａｖ１．７が関与する疾患、具体的には神経障害性疼痛、侵害受容性疼痛、炎症性疼痛、小径線維ニューロパチー、肢端紅痛症、発作性激痛症、排尿障害または多発性硬化症等の治療薬の提供。【解決手段】式（１）で表される化合物。[Ｒ１a〜Ｒ１ｄはＨ、シアノ、Ｃ１−４アルキル等；Ｒ２及びＲ３Ｈ、Ｃ１−６アルキル、Ｃ３−１０シクロアルキル、３〜７員の複素環等；ＬはＣＲ４Ｒ５；Ｒ４及びＲ５はＨ、水酸基、Ｃ１−４アルキル等；ｍは１〜３]【選択図】なし</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDz8w9z9VFwcvWL8vT1dHGM8vdxVXBxDfIMcwzxDHNVcPRzUfB1dfF0dvRRcAwI8AEyQjz9_RRCPFyDXP3deBhY0xJzilN5oTQ3g5Kba4izh25qQX58anFBYnJqXmpJvFeAkYGhhYGpkYWhuaMxUYoAt24qpA</recordid><startdate>20180405</startdate><enddate>20180405</enddate><creator>ADACHI KEIJI</creator><creator>IWAMOTO KOHEI</creator><creator>SAWAYAMA YUSUKE</creator><creator>KIYOSHIGE SAORI</creator><creator>YAMAI YUSUKE</creator><scope>EVB</scope></search><sort><creationdate>20180405</creationdate><title>NOVEL BENZIMIDAZOLE DERIVATIVE AND MEDICAL APPLICATION THEREOF</title><author>ADACHI KEIJI ; IWAMOTO KOHEI ; SAWAYAMA YUSUKE ; KIYOSHIGE SAORI ; YAMAI YUSUKE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2018052817A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>ADACHI KEIJI</creatorcontrib><creatorcontrib>IWAMOTO KOHEI</creatorcontrib><creatorcontrib>SAWAYAMA YUSUKE</creatorcontrib><creatorcontrib>KIYOSHIGE SAORI</creatorcontrib><creatorcontrib>YAMAI YUSUKE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ADACHI KEIJI</au><au>IWAMOTO KOHEI</au><au>SAWAYAMA YUSUKE</au><au>KIYOSHIGE SAORI</au><au>YAMAI YUSUKE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL BENZIMIDAZOLE DERIVATIVE AND MEDICAL APPLICATION THEREOF</title><date>2018-04-05</date><risdate>2018</risdate><abstract>PROBLEM TO BE SOLVED: To provide a therapeutic agent for diseases to which Nav1.7 relates, especially neuropathic pain, nociceptive pain, inflammatory pain, small diameter fibrous neuropathy, erythromelalgia, paroxysmal pain, dysuria or multiple sclerosis or the like.SOLUTION: There is provided a compound represented by the formula (1), where Rto Rare H, cyano, Calkyl or the like, Rand Rare H, Calkyl, Ccycloalkyl, 3- to 7-membered heterocycle or the like, L is CRR, Rand Rare H, hydroxyl group, Calkyl or the like and m is 1 to 3.SELECTED DRAWING: None
【課題】Ｎａｖ１．７が関与する疾患、具体的には神経障害性疼痛、侵害受容性疼痛、炎症性疼痛、小径線維ニューロパチー、肢端紅痛症、発作性激痛症、排尿障害または多発性硬化症等の治療薬の提供。【解決手段】式（１）で表される化合物。[Ｒ１a〜Ｒ１ｄはＨ、シアノ、Ｃ１−４アルキル等；Ｒ２及びＲ３Ｈ、Ｃ１−６アルキル、Ｃ３−１０シクロアルキル、３〜７員の複素環等；ＬはＣＲ４Ｒ５；Ｒ４及びＲ５はＨ、水酸基、Ｃ１−４アルキル等；ｍは１〜３]【選択図】なし</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVEL BENZIMIDAZOLE DERIVATIVE AND MEDICAL APPLICATION THEREOF |
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