NOVEL BENZIMIDAZOLE DERIVATIVE AND MEDICAL APPLICATION THEREOF

PROBLEM TO BE SOLVED: To provide a therapeutic agent for diseases to which Nav1.7 relates, especially neuropathic pain, nociceptive pain, inflammatory pain, small diameter fibrous neuropathy, erythromelalgia, paroxysmal pain, dysuria or multiple sclerosis or the like.SOLUTION: There is provided a compound represented by the formula (1), where Rto Rare H, cyano, Calkyl or the like, Rand Rare H, Calkyl, Ccycloalkyl, 3- to 7-membered heterocycle or the like, L is CRR, Rand Rare H, hydroxyl group, Calkyl or the like and m is 1 to 3.SELECTED DRAWING: None 【課題】Ｎａｖ１．７が関与する疾患、具体的には神経障害性疼痛、侵害受容性疼痛、炎症性疼痛、小径線維ニューロパチー、肢端紅痛症、発作性激痛症、排尿障害または多発性硬化症等の治療薬の提供。【解決手段】式（１）で表される化合物。[Ｒ１a〜Ｒ１ｄはＨ、シアノ、Ｃ１−４アルキル等；Ｒ２及びＲ３Ｈ、Ｃ１−６アルキル、Ｃ３−１０シクロアルキル、３〜７員の複素環等；ＬはＣＲ４Ｒ５；Ｒ４及びＲ５はＨ、水酸基、Ｃ１−４アルキル等；ｍは１〜３]【選択図】なし