PARTICLE OF MODIFIED SILICA

PROBLEM TO BE SOLVED: To provide a particle of modified silica that can be used as a stationary phase for chromatography, a method of preparing the same, and a chromatography separation column.SOLUTION: A particle of modified silica can be obtained by having a silica particle react with a halohydrin...

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Hauptverfasser:	PER ANDERS RESTORP, ANDERS TOERNCRONA, JOHAN LIF, JOAKIM ERIK PATRIK HOEGBLOM
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY COMPOUNDS THEREOF INORGANIC CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY NON-METALLIC ELEMENTS PHYSICS TESTING
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a particle of modified silica that can be used as a stationary phase for chromatography, a method of preparing the same, and a chromatography separation column.SOLUTION: A particle of modified silica can be obtained by having a silica particle react with a halohydrin compound. The halohydrin compound is an organic compound containing adjacent carbon atoms, where one carbon has a halogen substituent and another carbon has a hydroxyl group. The halohydrin compound can be obtained using, for example, epichlorohydrin as a starting material.SELECTED DRAWING: None 【課題】クロマトグラフィーの固定相として使用可能な変性シリカ粒子、その調製方法及びクロマトグラフィー分離カラムを提供する。【解決手段】ハロヒドリン化合物とシリカ粒子を反応させることにより、変性シリカ粒子を得ることが出来る。ハロヒドリン化合物は、隣接する炭素原子を含む有機化合物であり、ここで、１個の炭素はハロゲン置換基を有し、他の炭素はヒドロキシル基を有する。ハロヒドリン化合物は、例えばエピクロルヒドリンを出発原料として得ることが出来る。【選択図】なし