METHOD FOR PRODUCING INTERMEDIATE OF BIOTIN, AND METHOD FOR PRODUCING BIOTIN

METHOD FOR PRODUCING INTERMEDIATE OF BIOTIN, AND METHOD FOR PRODUCING BIOTIN

PROBLEM TO BE SOLVED: To provide method for producing an amidealcohol compound, an intermediate of biotin, and a method for producing biotin using the intermediate.SOLUTION: A method for producing an amidealcohol compound includes reducing a compound represented by formula (1) with (i) NaAlH(OCHCHOC...

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Bibliographische Detailangaben
Hauptverfasser: YAMAMOTO HIROMASA, TANAKA KENJI, IWASAKI FUMIAKI, SEKI MASAHIKO, SEIKE YOSHIKI
Format: Patent
Sprache:eng ; jpn
Schlagworte:
CHEMISTRY
CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS
GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide method for producing an amidealcohol compound, an intermediate of biotin, and a method for producing biotin using the intermediate.SOLUTION: A method for producing an amidealcohol compound includes reducing a compound represented by formula (1) with (i) NaAlH(OCHCHOCH)and then reducing it with borohydride metal salt or (ii) borohydride calcium. {R1 and R2 independently represent H or a protecting group of a ureylene group; R4 is an alkyl group, an aralkyl group or an aryl group; R5-R7 independently represent H, an alkyl group, an alkoxy group or a halogen atom.}SELECTED DRAWING: None 【課題】ビオチンの中間体であるアミドアルコール化合物の製造方法、該中間体を用いたビオチンの製造方法の提供。【解決手段】式（１）で示される化合物を、（ｉ）ＮａＡｌＨ２（Ｏ２ＣＨ２ＣＨ２ＯＣＨ３）２で還元した後、水素化ホウ素金属塩で、又は（ｉｉ）水素化ホウ素カルシウムで還元することによる、アミドアルコール化合物の製造方法。｛Ｒ１及びＲ２は夫々独立にＨ又はウレイレン基の保護基；Ｒ４は、アルキル基、アラルキル基又はアリール基；Ｒ５〜Ｒ７は夫々独立にＨ、アルキル基、アルコキシ基又はハロゲン原子｝【選択図】なし