IMMUNOREGULATORY COMPOSITION, USE FOR PRODUCING IMMUNOREGULATORY COMPOSITION, PRODUCTION METHOD OF IMMUNOREGULATORY COMPOSITION, AND PRODUCTION METHOD OF FOODS, PHARMACEUTICAL DRUGS, AND ANIMAL FEEDING PRODUCTS USING IMMUNOREGULATORY COMPOSITION

PROBLEM TO BE SOLVED: To provide immunoregulatory compositions which can induce production of IL-10 having a function of suppressing excessive immune responses and in which the induction of the production of IL-12 having a function of inducing excessive immune responses is suppressed.SOLUTION: An immunoregulatory composition containing bacterial cells and/or processed products thereof as an active ingredient is provided, the bacterial cells of a microorganism and/or processed products thereof having 20% or more of IL-10 production inducing ability based on the IL-10 production inducing ability of OK432 and having IL-12 production inducing ability not exceeding 30% based on IL-12 production inducing ability of OK432. Preferably, the bacterial cells of a microorganism, and/or processed products thereof has 30% or more of IL-10 production inducing ability based on IL-10 production inducing ability of OK432 and has IL-12 production inducing ability not exceeding 30% based on IL-12 production inducing ability of OK432.SELECTED DRAWING: Figure 1 【課題】過剰な免疫応答を抑える働きをもつＩＬ−１０の産生を誘導させることができ、且つ、過剰な免疫応答を引き起こす働きをもつＩＬ−１２の産生の誘導が抑えられた免疫調節用組成物を提供する。【解決手段】微生物の菌体及び／又はその処理物であって、ＯＫ４３２のＩＬ−１０産生誘導能を基準にして２０％以上のＩＬ−１０産生誘導能を有し、且つ、ＯＫ４３２のＩＬ−１２産生誘導能を基準にして３０％を超えないＩＬ−１２産生誘導能を有する、該菌体及び／又はその処理物を有効成分とする免疫調節用組成物を提供する。前記微生物の菌体及び／又はその処理物は、ＯＫ４３２のＩＬ−１０産生誘導能を基準にして３０％以上のＩＬ−１０産生誘導能を有し、且つ、ＯＫ４３２のＩＬ−１２産生誘導能を基準にして３０％を超えないＩＬ−１２産生誘導能を有することが好ましい。【選択図】 図１