SUBSTITUTED PHENYL COMPOUND
PROBLEM TO BE SOLVED: To provide a substituted phenyl compound having prostaglandin E-like agonist action, particularly EP2-selective agonist action, wherein the substituted phenyl compound has excellent pulmonary fibroblast proliferation inhibitory action and is suitable for pneumonitis/pulmonary f...
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| creator | KANDA TOMOKO USHIYAMA SHIGERU IWASE NORIAKI SHIBAKAWA NOBUHIKO YONEDA KENJI |
| description | PROBLEM TO BE SOLVED: To provide a substituted phenyl compound having prostaglandin E-like agonist action, particularly EP2-selective agonist action, wherein the substituted phenyl compound has excellent pulmonary fibroblast proliferation inhibitory action and is suitable for pneumonitis/pulmonary fibrosis therapeutic and/or preventive agents.SOLUTION: This invention relates to a substituted phenyl compound represented by formula (I) or pharmacologically acceptable salt thereof (Ris a carboxy group that may be protected; Q is O or a group -CH-; W is N or a group -CH=; Ris an ethoxy group, a 1-propenyl group or a 1-propynyl group; Z is a phenyl group or a specific group).SELECTED DRAWING: None
【課題】プロスタグランジンＥ２様のアゴニスト作用、特にＥＰ２選択的なアゴニスト作用を有する置換フェニル化合物は、優れた肺線維芽細胞増殖抑制作用を有し、間質性肺炎・肺線維症治療薬及び／又は予防薬の提供。【解決手段】式（Ｉ）で表される置換フェニル化合物又はその薬理上許容される塩。（Ｒ１は保護されていてもよいカルボキシ基；ＱはＯ又は基−ＣＨ２−；ＷはＮ又は基−ＣＨ＝；Ｒ２はエトキシ基、１−プロペニル基又は１−プロピニル基；Ｚはフェニル基又は特定の基を示す）【選択図】なし |
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【課題】プロスタグランジンＥ２様のアゴニスト作用、特にＥＰ２選択的なアゴニスト作用を有する置換フェニル化合物は、優れた肺線維芽細胞増殖抑制作用を有し、間質性肺炎・肺線維症治療薬及び／又は予防薬の提供。【解決手段】式（Ｉ）で表される置換フェニル化合物又はその薬理上許容される塩。（Ｒ１は保護されていてもよいカルボキシ基；ＱはＯ又は基−ＣＨ２−；ＷはＮ又は基−ＣＨ＝；Ｒ２はエトキシ基、１−プロペニル基又は１−プロピニル基；Ｚはフェニル基又は特定の基を示す）【選択図】なし</description><language>eng ; jpn</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171124&DB=EPODOC&CC=JP&NR=2017206444A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20171124&DB=EPODOC&CC=JP&NR=2017206444A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KANDA TOMOKO</creatorcontrib><creatorcontrib>USHIYAMA SHIGERU</creatorcontrib><creatorcontrib>IWASE NORIAKI</creatorcontrib><creatorcontrib>SHIBAKAWA NOBUHIKO</creatorcontrib><creatorcontrib>YONEDA KENJI</creatorcontrib><title>SUBSTITUTED PHENYL COMPOUND</title><description>PROBLEM TO BE SOLVED: To provide a substituted phenyl compound having prostaglandin E-like agonist action, particularly EP2-selective agonist action, wherein the substituted phenyl compound has excellent pulmonary fibroblast proliferation inhibitory action and is suitable for pneumonitis/pulmonary fibrosis therapeutic and/or preventive agents.SOLUTION: This invention relates to a substituted phenyl compound represented by formula (I) or pharmacologically acceptable salt thereof (Ris a carboxy group that may be protected; Q is O or a group -CH-; W is N or a group -CH=; Ris an ethoxy group, a 1-propenyl group or a 1-propynyl group; Z is a phenyl group or a specific group).SELECTED DRAWING: None
【課題】プロスタグランジンＥ２様のアゴニスト作用、特にＥＰ２選択的なアゴニスト作用を有する置換フェニル化合物は、優れた肺線維芽細胞増殖抑制作用を有し、間質性肺炎・肺線維症治療薬及び／又は予防薬の提供。【解決手段】式（Ｉ）で表される置換フェニル化合物又はその薬理上許容される塩。（Ｒ１は保護されていてもよいカルボキシ基；ＱはＯ又は基−ＣＨ２−；ＷはＮ又は基−ＣＨ＝；Ｒ２はエトキシ基、１−プロペニル基又は１−プロピニル基；Ｚはフェニル基又は特定の基を示す）【選択図】なし</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJAODnUKDvEMCQ1xdVEI8HD1i_RRcPb3DfAP9XPhYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxXgFGBobmRgZmJiYmjsZEKQIAtOIhRw</recordid><startdate>20171124</startdate><enddate>20171124</enddate><creator>KANDA TOMOKO</creator><creator>USHIYAMA SHIGERU</creator><creator>IWASE NORIAKI</creator><creator>SHIBAKAWA NOBUHIKO</creator><creator>YONEDA KENJI</creator><scope>EVB</scope></search><sort><creationdate>20171124</creationdate><title>SUBSTITUTED PHENYL COMPOUND</title><author>KANDA TOMOKO ; USHIYAMA SHIGERU ; IWASE NORIAKI ; SHIBAKAWA NOBUHIKO ; YONEDA KENJI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2017206444A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>KANDA TOMOKO</creatorcontrib><creatorcontrib>USHIYAMA SHIGERU</creatorcontrib><creatorcontrib>IWASE NORIAKI</creatorcontrib><creatorcontrib>SHIBAKAWA NOBUHIKO</creatorcontrib><creatorcontrib>YONEDA KENJI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KANDA TOMOKO</au><au>USHIYAMA SHIGERU</au><au>IWASE NORIAKI</au><au>SHIBAKAWA NOBUHIKO</au><au>YONEDA KENJI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED PHENYL COMPOUND</title><date>2017-11-24</date><risdate>2017</risdate><abstract>PROBLEM TO BE SOLVED: To provide a substituted phenyl compound having prostaglandin E-like agonist action, particularly EP2-selective agonist action, wherein the substituted phenyl compound has excellent pulmonary fibroblast proliferation inhibitory action and is suitable for pneumonitis/pulmonary fibrosis therapeutic and/or preventive agents.SOLUTION: This invention relates to a substituted phenyl compound represented by formula (I) or pharmacologically acceptable salt thereof (Ris a carboxy group that may be protected; Q is O or a group -CH-; W is N or a group -CH=; Ris an ethoxy group, a 1-propenyl group or a 1-propynyl group; Z is a phenyl group or a specific group).SELECTED DRAWING: None
【課題】プロスタグランジンＥ２様のアゴニスト作用、特にＥＰ２選択的なアゴニスト作用を有する置換フェニル化合物は、優れた肺線維芽細胞増殖抑制作用を有し、間質性肺炎・肺線維症治療薬及び／又は予防薬の提供。【解決手段】式（Ｉ）で表される置換フェニル化合物又はその薬理上許容される塩。（Ｒ１は保護されていてもよいカルボキシ基；ＱはＯ又は基−ＣＨ２−；ＷはＮ又は基−ＣＨ＝；Ｒ２はエトキシ基、１−プロペニル基又は１−プロピニル基；Ｚはフェニル基又は特定の基を示す）【選択図】なし</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | SUBSTITUTED PHENYL COMPOUND |
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