SUBSTITUTED PHENYL COMPOUND

PROBLEM TO BE SOLVED: To provide a substituted phenyl compound having prostaglandin E-like agonist action, particularly EP2-selective agonist action, wherein the substituted phenyl compound has excellent pulmonary fibroblast proliferation inhibitory action and is suitable for pneumonitis/pulmonary fibrosis therapeutic and/or preventive agents.SOLUTION: This invention relates to a substituted phenyl compound represented by formula (I) or pharmacologically acceptable salt thereof (Ris a carboxy group that may be protected; Q is O or a group -CH-; W is N or a group -CH=; Ris an ethoxy group, a 1-propenyl group or a 1-propynyl group; Z is a phenyl group or a specific group).SELECTED DRAWING: None 【課題】プロスタグランジンＥ２様のアゴニスト作用、特にＥＰ２選択的なアゴニスト作用を有する置換フェニル化合物は、優れた肺線維芽細胞増殖抑制作用を有し、間質性肺炎・肺線維症治療薬及び／又は予防薬の提供。【解決手段】式（Ｉ）で表される置換フェニル化合物又はその薬理上許容される塩。（Ｒ１は保護されていてもよいカルボキシ基；ＱはＯ又は基−ＣＨ２−；ＷはＮ又は基−ＣＨ＝；Ｒ２はエトキシ基、１−プロペニル基又は１−プロピニル基；Ｚはフェニル基又は特定の基を示す）【選択図】なし