COMBINATION OF SUBSTITUTED BIARYL COMPOUND AND ANOTHER MEDICINE

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition useful as a therapeutic and/or preventive agent of a respiratory disease such as asthma, the pharmaceutical composition to be administered in combined with another medicine such as a phosphodiesterase 4 inhibitor.SOLUTION: The present invention provides a pharmaceutical composition containing a substituted biaryl compound represented by formula (I), or a pharmacologically acceptable salt thereof [Ris a carboxyl group, which may be protected; W is nitrogen or a -CH= group; Ris an ethoxy group, a 1-propenyl group or a 1-propynyl group; Z is a phenyl group, a 3-fluorophenyl group, a pyridine-2-yl group, a pyridine-3-yl group, a thiophene-2-yl group, or a thiophene-3-yl group].SELECTED DRAWING: None 【課題】喘息等の呼吸器疾患に対する治療薬及び／又は予防薬として有用な医薬組成物であって、ホスホジエステラーゼ４阻害薬等の他の医薬と組み合わせて投与される医薬組成物の提供。【解決手段】式（Ｉ）に示される置換ビアリール化合物、又はその薬理上許容される塩を含む医薬組成物。［Ｒ１は保護されていてもよいカルボキシル基；Ｗは窒素又は−ＣＨ＝基；Ｒ２はエトキシ基、１−プロペニル基又は１−プロピニル基；Ｚはフェニル基、３−フルオロフェニル基、ピリジン−２−イル基、ピリジン−３−イル基、チオフェン−２−イル基、又はチオフェン−３−イル基］【選択図】なし