3,4-DIHYDROISOQUINOLIN-2(1H)-YL COMPOUNDS

PROBLEM TO BE SOLVED: To provide novel positive allosteric modulators (PAMs) of the dopamine 1 receptor (D1).SOLUTION: The invention provides certain 3,4-dihydroisoquinolin-2(1H)-yl compounds, particularly compounds of formula (I), and pharmaceutical compositions thereof. The invention further provi...

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Hauptverfasser:	CRAIG DANIEL WOLFANGEL, MATTHEW ROBERT REINHARD, CHRISTOPHER DAVID BEADLE, JOSEPH HERMAN KRUSHINSKI JR, JOHN MEHNERT SCHAUS, HAO JUNLIANG, DAVID ANDREW COATES
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide novel positive allosteric modulators (PAMs) of the dopamine 1 receptor (D1).SOLUTION: The invention provides certain 3,4-dihydroisoquinolin-2(1H)-yl compounds, particularly compounds of formula (I), and pharmaceutical compositions thereof. The invention further provides methods of using the compounds to treat cognitive impairment associated with Parkinson's disease or schizophrenia.SELECTED DRAWING: None 【課題】新規ドーパミン１受容体（Ｄ１）の正のアロステリック調節因子（ＰＡＭ）の提供。【解決手段】特定の３，４−ジヒドロイソキノリン−２（１Ｈ）−イル化合物、特に、式（Ｉ）の化合物、及びその医薬組成物。更に、パーキンソン病又は統合失調症と関連する認知障害を治療するために前記化合物を使用する方法。【選択図】なし