AGES-RELATED REACTION INHIBITOR, PROPHYLACTIC/THERAPEUTIC AGENT FOR AGES-RELATED DISEASES, AND SUPPLEMENT, FUNCTIONAL FOOD, AND COSMETIC COMPOSITION

PROBLEM TO BE SOLVED: To provide a pharmaceutical agent that inhibits the relevant reaction of AGEs caused by chemical glycation of proteins.SOLUTION: According to the present invention, an AGEs-related reaction inhibitor comprises: one or more selected from quercetin and quercetin glycoside as component (A); and one or more selected from sulforaphane and sulforaphane glycoside as component (B) as active ingredients. The AGEs-related reaction inhibitor inhibits all of the following: (1) formation of AGEs; (2) expression of the AGEs receptor (RAGE) gene; and (3) binding between AGEs and AGEs receptor (RAGE).SELECTED DRAWING: Figure 5 【課題】タンパク質の化学的糖化によって生じるＡＧＥｓの関連反応を抑制する薬剤を提供する。【解決手段】成分（Ａ）としてケルセチン及びケルセチン配糖体から選択される１種以上、並びに成分（Ｂ）としてスルフォラファン及びスルフォラファン配糖体から選択される１種以上を有効成分として含有し、下記の（１）〜（３）の全てを抑制するＡＧＥｓ関連反応抑制剤。（１）ＡＧＥｓの形成（２）ＡＧＥｓ受容体（ＲＡＧＥ）遺伝子の発現（３）ＡＧＥｓとＡＧＥｓ受容体（ＲＡＧＥ）との結合【選択図】図５