METHODS FOR PROGNOSIS AND TREATMENT OF AKT3 RELATED CONDITIONS

PROBLEM TO BE SOLVED: To provide methods for prognosis and treatment of cancers associated with protein kinases.SOLUTION: The invention provides a method for identifying a subject in which epithelial-to-mesenchymal transition (EMT) is occurring, the method comprising a step of determining the Akt3 expression or activity level in a sample derived from the subject, where the increase in the Akt3 expression or activity level indicates the occurrence of EMT. Also provided is a use of Akt3 as a biomarker for detecting EMT in a subject as well as a use of an Akt3 inhibitor for treating cancer. Also provided is a method for detecting the occurrence of EMT in a subject by determining Akt3 expression and/or activity. Also provided is a method in which increase in the Akt3 expression or activity level indicates the occurrence of EMT which indicates increased risk of occurrence of metastatic cancer or drug-resistant cancer.SELECTED DRAWING: Figure 2 【課題】プロテインキナーゼ関連の癌の予知及び治療方法を提供する。【解決手段】上皮間葉転換（ＥＭＴ）が起きている対象を特定する方法であって、前記対象から得た試料におけるＡｋｔ３の発現レベル又は活性レベルを対照試料と比較して決定するステップ、を含み、Ａｋｔ３の発現レベル又は活性レベルの増加が、ＥＭＴの発生を示す、方法。対象におけるＥＭＴの発生の検出用バイオマーカーとしてのＡｋｔ３の使用、及び癌を治療するためにＡｋｔ３阻害薬の使用。また、Ａｋｔ３発現及び／又は活性を測定することにより対象における上皮間葉転換（ＥＭＴ）の発生を検出するための方法。Ａｋｔ３の発現レベル又は活性レベルの増加はＥＭＴの発生を示し、ＥＭＴの発生は転移性癌又は薬物耐性癌発生リスクの増加を示す、方法。【選択図】図２