NIEMANN-PICK DISEASE TYPE C PREVENTIVE AND/OR THERAPEUTIC AGENT

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition that has the action to improve decreases in the stability of NPC1 mutant and folding efficiency and is useful for the prevention and/or treatment of Niemann-Pick disease type C.SOLUTION: A Niemann-Pick disease type C preventive and/or therapeutic agent comprises a compound represented by formula (I), its ester or salt as an active ingredient (Ar-Arindependently represent a substituted/unsubstituted aromatic group; Xis CHor O; preferably Aris 4-alkyl-1,2,4-triazole-5-one group).SELECTED DRAWING: Figure 2D 【課題】ＮＰＣ１変異体の安定性及びフォールディング効率の低下を改善する作用を有し、ニーマンピック病Ｃ型の予防及び／又は治療のために有用な医薬組成物の提供。【解決手段】式（Ｉ）で示される化合物、そのエステル又は塩を有効成分として含有するニーマンピック病Ｃ型の予防及び／又は治療剤。（Ａｒ１〜Ａｒ３は各々独立に置換／非置換の芳香族基；Ｘ１はＣＨ２又はＯ；好ましくはＡｒ３が４−アルキル−１，２，４−トリアゾール−５−オン基）【選択図】図２Ｄ