MOLECULAR DIAGNOSTIC TEST FOR CANCER

PROBLEM TO BE SOLVED: To provide methods of predicting the responsiveness to anti- angiogenesis therapeutic agents.SOLUTION: A method comprises measuring expression levels of one biomarker of a particular gene biomarker group in a test sample of diseased tissue obtained from the subject to determine...

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Hauptverfasser:	LAURA A HILL, MAX BYLESJO, STEVE DEHARO, ANDRENA MCCAVIGAN, DENNIS PAUL HARKIN, CLAIRE TRINDER, VITALI PROUTSKI, TIMOTHY DAVISON, ANDREAS WINTER, FIONNUALA PATTERSON, CAROLINE MICHIE, KATHERINE E KEATING, JUDE O'DONNELL, CHARLIE GOURLEY, RICHARD KENNEDY, EAMONN J O'BRIEN
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide methods of predicting the responsiveness to anti- angiogenesis therapeutic agents.SOLUTION: A method comprises measuring expression levels of one biomarker of a particular gene biomarker group in a test sample of diseased tissue obtained from the subject to determine a sample expression score; comparing the sample expression score to a threshold expression score; and classifying the subject as responsive or non-responsive, based on whether the sample expression score is above or below the threshold expression score.SELECTED DRAWING: None 【課題】抗血管形成治療薬に対する応答性を予測する方法の提供【解決手段】特定の遺伝子バイオマーカー群の１つのバイオマーカーの発現レベルを、前記対象から得た疾患組織の検査試料において測定して試料発現スコアを決定すること、前記試料発現スコアを閾値発現スコアと比較すること、および前記試料発現スコアが前記閾値発現スコアより上回るかまたは下回るかに基づいて、前記対象を応答性または非応答性であると分類することを含む方法。【選択図】なし