COMPOSITION HAVING COMBINATION OF IMMEDIATE RELEASE AND CONTROLLED RELEASE PROPERTIES

PROBLEM TO BE SOLVED: To provide a formulation of a low solubility active substance having a combination of immediate release and controlled release properties of the active substance.SOLUTION: The present invention provides a composition that comprises: particles of at least one low solubility nanoparticulate active substance particles; at least one surface stabilizer adsorbed onto the surface of the nanoparticulate active substance particles, the stabilizer having the function of stabilizing a nanoparticulate active substance by preventing agglomeration and an increase in particle diameter; and at least one low solubility micronized active substance, which is either the same as or different from the active substance.SELECTED DRAWING: Figure 1 【課題】活性物質の即時放出および徐放特性の組み合わせを有する溶解度の低い活性物質の製剤を提供。【解決手段】少なくとも１つの溶解度の低いナノ微粒子活性物質の粒子とナノ微粒子活性物質粒子の表面に吸着した、アグロメレーションおよび粒径の増大を防止することによりナノ微粒子活性物質を安定化する機能を有する少なくとも１つの表面安定化剤、および前記活性物質と同一のまたは異なる、少なくとも１つの溶解度の低いミクロ微粒子活性物質からなる組成物。【選択図】図１