ANTIBODY TO M-CSF

PROBLEM TO BE SOLVED: To provide an isolated human antibody or antigen binding portion thereof specifically binding to human M-CSF and acting as an M-CSF antagonist, and a composition comprising such an antibody or antigen binding portion.SOLUTION: The present invention provides: an antibody that sp...

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Bibliographische Detailangaben
Hauptverfasser:	BEDIAN VAHE, KELLERMANN SIRID-AIMEE, DEVALARAJA MADHAV NARASIMHA, LOW JOSEPH EDWIN, MOBLEY JAMES LESLIE, HAAK-FRENDSCHO MARY, FOLTZ IAN
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CALCULATING CHEMISTRY COMPOSITIONS THEREOF COMPUTING COUNTING CULTURE MEDIA DATA PROCESSING SYSTEMS OR METHODS, SPECIALLY ADAPTED FORADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORYOR FORECASTING PURPOSES ELECTRIC DIGITAL DATA PROCESSING ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE,COMMERCIAL, FINANCIAL, MANAGERIAL, SUPERVISORY OR FORECASTINGPURPOSES, NOT OTHERWISE PROVIDED FOR VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide an isolated human antibody or antigen binding portion thereof specifically binding to human M-CSF and acting as an M-CSF antagonist, and a composition comprising such an antibody or antigen binding portion.SOLUTION: The present invention provides: an antibody that specifically binds to an M-CSF, preferably human M-CSF, and functions to inhibit M-CSF, and an antigen-binding portion thereof; a human anti-M-CSF antibody and an antigen binding portion thereof; a composition containing such an antibody or an antigen binding portion; and a nucleic acid molecules that encode a compound constructing such a composition. The present invention also provides a human anti-M-CSF antibody; a method for preparing a composition containing such an antibody; a method for using the antibody and composition for diagnosis and therapy; a method for gene therapy using a nucleic acid molecule encoding a heavy chain and/or a light chain of an immunoglobulin molecule, including the human anti-M-CSF antibodies; etc.SELECTED DRAWING: Figure 1A 【課題】ヒトＭ−ＣＳＦに特異的に結合し、またＭ−ＣＳＦアンタゴニストとして作用する、単離されたヒト抗体もしくはこの抗原結合部分、およびこのような抗体または抗原結合部分を含む組成物の提供。【解決手段】Ｍ−ＣＳＦ、好ましくはヒトＭ−ＣＳＦに特異的に結合し、またＭ−ＣＳＦを阻害するように機能する抗体、およびこの抗原結合部分、ヒト抗Ｍ−ＣＳＦ抗体、およびこの抗原結合部分、さらにこのような抗体または抗原結合部分を含む組成物、このような組成物を構成する化合物をコードする核酸分子の提供。ヒト抗Ｍ−ＣＳＦ抗体、このような抗体を含む組成物を作製する方法、ならびに抗体および組成物を診断および治療に使用する方法、該ヒト抗Ｍ−ＣＳＦ抗体を含む、重鎖および/または軽鎖の免疫グロブリン分子をコードする核酸分子を用いる遺伝子治療法等の提供。【選択図】図１Ａ