TERPENOID ANALOGS FOR TREATING ELECTRICAL DISORDERS IN CENTRAL NERVOUS SYSTEM AND PERIPHERAL NERVOUS SYSTEM AND USES THEREOF

PROBLEM TO BE SOLVED: To provide terpenoid analogs for treating pain, and to provide a method of using the same with the aim of treating pain.SOLUTION: A method for treating electrical disorders in the central nervous system and peripheral nervous system comprises administering into animals (excludi...

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Bibliographische Detailangaben
Hauptverfasser: WEAVER DONALD, SUN SHENGGUO, MCLELLAN ALEXANDER, LU ERHU, MARK A REED
Format: Patent
Sprache:eng ; jpn
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide terpenoid analogs for treating pain, and to provide a method of using the same with the aim of treating pain.SOLUTION: A method for treating electrical disorders in the central nervous system and peripheral nervous system comprises administering into animals (excluding humans) a therapeutically effective amount of a terpene analogue represented by the following formula or a pharmaceutically acceptable salt thereof[Y is an unsubstituted C1-C20 alkylene group, C=O or the like; X is N-(R2) 2 or a substituted C1-C20 alkyl group; R1 is H, a substituted/unsubstituted C1-C20 alkyl group or a substituted/unsubstituted CH-aryl; R2 is each independently H, a substituted/unsubstituted C1-C20 alkyl group, an aryl group, OR, CN, or C(=O) R; R 3 is a substituted/unsubstituted C1-C20 alkyl group substituted/unsubstituted aryl group; W is an unsubstituted C1-C20 alkyl group or an unsubstituted aryl group.]SELECTED DRAWING: None 【課題】疼痛を治療するためのテルペノイド類似体と、疼痛の治療を目的とするその使用方法の提供。【解決手段】下記式のテルペン類似体、またはその薬学的に許容される塩の治療有効量を動物(ヒトを除く)に投与するステップを含む、中枢神経系および末梢神経系における電気的障害を治療する方法[Yは非置換のC1〜C20アルキレン基、C=O等;XはN−(R2)2又は置換のC1〜C20アルキル基;R1は、H、置換/非置換のC1〜20アルキル基又は置換/非置換のCH2−アリール;R2は夫々独立にH、置換/非置換のC1〜C20アルキル基、アリール基、OR1、CN、又はC(=O)R3;R3は、置換/非置換のC1〜20アルキル基置換/非置換のアリール基;Wは非置換のC1〜C20アルキル基又は非置換のアリール基]【選択図】なし