USE OF ADRENAL HORMONE MODIFYING AGENT

PROBLEM TO BE SOLVED: To provide a method for treating diseases or disorders which is characterized by an increased stress hormone level and/or a decreased androgen hormone level in a subject.SOLUTION: A method for treating diseases or disorders which is characterized by an increased stress hormone...

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Bibliographische Detailangaben
Hauptverfasser: PAPILLON JULIEN, HU QI-YING, MEREDITH ERIK, CHRISTOPH SCHUMACHER, GARY KSANDER, MONOVICH LAUREN G
Format: Patent
Sprache:eng ; jpn
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a method for treating diseases or disorders which is characterized by an increased stress hormone level and/or a decreased androgen hormone level in a subject.SOLUTION: A method for treating diseases or disorders which is characterized by an increased stress hormone level and/or a decreased androgen hormone level in a subject includes a process of administering a therapeutically effective amount of a compound expressed by formula (I) or pharmaceutically acceptable salt thereof to the subject. (R denotes H or -C(O)N(R)(R); each of Rand Rindependently denotes alkyl of -Ctoor aryl of -Ctoalkyl -Cto, Rand Rmay be substituted with alkoxy of -Cto C; each of Rto Rindependently denotes H, halogen, cyano or aryl of Cto; Rand Rdenote H)SELECTED DRAWING: None 【課題】被験体における増加したストレスホルモンレベルおよび/または減少したアンドロゲンホルモンレベルを特徴とする疾患または障害の治療方法の提供。【解決手段】式(I)で表される化合物、または医薬的に許容可能なその塩の治療有効量を被験体に投与する工程を含む、被験体における増加したストレスホルモンレベルおよび/または減少したアンドロゲンホルモンレベルを特徴とする疾患または障害の治療方法。(RはH又は−C(O)N(Ra)(Rb);Ra及びRbは各々独立に、−C1〜4のアルキル又は−C1〜4アルキル−C5〜7のアリール、Ra及びRbは−C1〜C4のアルコキシに置換されても良い;R1〜R3は各々独立にH、ハロゲン、シアノ又はC6〜10のアリール;R4及びR5はH)【選択図】なし