PROTEINS THAT BIND PI16, AND USES THEREOF

PROBLEM TO BE SOLVED: To solve the following problem: there is a need in the art for new markers, preferably cell surface markers, which permit detection and isolation of Treg cells, or removal or destruction of Treg cells, e.g., for diagnostic, prognostic, therapeutic and/or prophylactic purposes.S...

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Bibliographische Detailangaben
Hauptverfasser:	HEDDY ZOLA, NICOLA GA-LING EASTAFF-LEUNG, IAN CAMERON NICHOLSON, SIMON BARRY, DOREEN KRUMBIEGEL
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To solve the following problem: there is a need in the art for new markers, preferably cell surface markers, which permit detection and isolation of Treg cells, or removal or destruction of Treg cells, e.g., for diagnostic, prognostic, therapeutic and/or prophylactic purposes.SOLUTION: The present disclosure provides an isolated protein comprising at least one antibody variable region that is capable of binding to peptidase inhibitor 16 (PI16), wherein the protein is also capable of competitively inhibiting binding of an antibody produced by a hybridoma designated CRCBT-02-001 deposited with the ATCC under Accession Number PTA-10685 to PI16. The present invention also provides use of the protein, e.g., in diagnosis, therapy or to isolate cells, preferably Treg cells.SELECTED DRAWING: None 【課題】例えば、診断目的で、予後予測目的で、治療目的で、および／または、予防目的でＴｒｅｇ細胞の検出と単離、または、Ｔｒｅｇ細胞の除去と破壊を可能にする新規のマーカー、好ましくは、細胞表面マーカーが当該分野において必要である。【解決手段】本開示は、ペプチダーゼインヒビター１６（ＰＩ１６）と結合することができる少なくとも１つの抗体可変領域を含む単離タンパク質を提供し、前記タンパク質はまた、ＰＴＡ−１０６８５の受託番号でＡＴＣＣに寄託されたＣＲＣＢＴ−０２−００１という名称のハイブリドーマにより産生された抗体のＰＩ１６への結合を競合的に阻害することができる。本発明はまた、例えば診断、治療の際の、または細胞、好ましくはＴｒｅｇ細胞を単離するためのタンパク質の使用を提供する。【選択図】なし