NOVEL CYCLIC HYDROCARBON COMPOUNDS FOR TREATMENT OF DISEASES

PROBLEM TO BE SOLVED: To provide compounds that are novel modulators, e.g., activators or agonists, of the human calcium sensing receptor (CaSR) and effective in treatment of chronic kidney disease and osteoporosis.SOLUTION: The invention provides a compound represented by the formula I or a pharmac...

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Bibliographische Detailangaben
Hauptverfasser:	SOPHIE ELISABETH HAVEZ, JEF FENSHOLDT, BJARNE NOERREMARK
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide compounds that are novel modulators, e.g., activators or agonists, of the human calcium sensing receptor (CaSR) and effective in treatment of chronic kidney disease and osteoporosis.SOLUTION: The invention provides a compound represented by the formula I or a pharmaceutically acceptable salt, solvate or in vivo hydrolyzable ester thereof, e.g., a compound of the formula (II) or the like.SELECTED DRAWING: Figure 2 【課題】慢性腎疾患や骨粗鬆症の処置に有効な、新規カルシウム感知受容体（ＣａＳＲ）の調節剤、例えば活性化剤又はアゴニストである化合物の提供。【解決手段】式Iで示される化合物または医薬的に許容されるその塩、溶媒和物もしくはインビボ加水分解性エステルであり、例えば、式（ＩＩ）の化合物等。式（Ｉ）式（ＩＩ）【選択図】図２