BRANCHED LINKER FOR PROTEIN-DRUG CONJUGATE

PROBLEM TO BE SOLVED: To provide a method for connecting protein and drug to obtain a protein-drug conjugate.SOLUTION: A drug is connected to protein through a specific branched linker, the branched linker contains a peptide chain, and is derived from o-hydroxy p-aminobenzyl alcohol. Herein, the pep...

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Hauptverfasser:	GAYLE PHILLIPS, JIN SHE, BERNHARD STUMP, HEILAM WONG, LAURENT DUCRY
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for connecting protein and drug to obtain a protein-drug conjugate.SOLUTION: A drug is connected to protein through a specific branched linker, the branched linker contains a peptide chain, and is derived from o-hydroxy p-aminobenzyl alcohol. Herein, the peptide chain is connected to a phenyl ring via p-amino group, the drug is connected to a phenyl ring via a benzyl alcohol portion, the protein is connected to a phenyl ring via an o-hydroxy group. A composition of such a protein-drug-conjugate can be used for controlling proliferation of undesirable cells, or the like.SELECTED DRAWING: None 【課題】タンパク質及び薬剤を連結して、タンパク質薬剤接合体を得るための方法の提供。【解決手段】薬剤は、特定の分枝リンカーを通してタンパク質に連結され、前記分枝リンカーは、ペプチド鎖を含み、ｏ−ヒドロキシｐ−アミノベンジルアルコールに由来し、ここで、ペプチド鎖は、ｐ−アミノ基を介してフェニル環に連結され、薬剤は、ベンジルアルコール部分を介してフェニル環に連結され、タンパク質は、ｏ−ヒドロキシ基を介してフェニル環に連結される。このようなタンパク質−薬剤−接合体の組成物は望ましくない細胞の増殖の制御などに使用できる。【選択図】なし