BIOMOLECULE MEASURING DEVICE AND BIOMOLECULE MEASURING METHOD

PROBLEM TO BE SOLVED: To achieve introduction of a biomolecule into a nanopore without confirmation of the position of the nanopore in a thin film, and secure displacement stability and achieve stable acquisition of a blockage signal.SOLUTION: A biomolecule fixing member 107 larger than the size of...

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Bibliographische Detailangaben
Hauptverfasser:	YANAGI ITARU, AKABORI REINA, TAKEDA KENICHI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	PROBLEM TO BE SOLVED: To achieve introduction of a biomolecule into a nanopore without confirmation of the position of the nanopore in a thin film, and secure displacement stability and achieve stable acquisition of a blockage signal.SOLUTION: A biomolecule fixing member 107 larger than the size of a thin film 113 having a nanopore 112 is used, and a biomolecule is fixed in a such density that at least one biomolecule 108 can enter an electric field area around the nanopore when the biomolecule fixing member 107 approaches a nanopore device 101.SELECTED DRAWING: Figure 1 【課題】ナノポアの薄膜内位置確認をせずに生体分子のナノポア内導入を実現する。また、変位安定性を確保し、安定した封鎖信号の取得を実現する。【解決手段】ナノポア１１２を有する薄膜１１３のサイズより大きな生体分子固定部材１０７を用い、生体分子固定部材１０７がナノポアデバイス１０１に近接した際にナノポア周辺の電場領域に少なくとも一本の生体分子１０８が入る密度で生体分子を固定する。【選択図】図１