HYPOALLERGENIC CHIMERIC PROTEINS BELONGING TO LIPID TRANSFER FAMILY OF PARIETARIA JUDAICA FOR USE IN ALLERGY TREATMENT
PROBLEM TO BE SOLVED: To provide hypoallergenic chimeric proteins belonging to the lipid transfer family of Parietaria judaica for use in allergy treatment.SOLUTION: The invention relates to recombinant DNA molecules encoding chimeric polypeptide of various allergens of Parietaria judaica usable for...
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| creator | MARTINEZ GARATE ALBERTO GONZALES RIOJA ROBERTO ASTURIAS ORTEGA JUAN ANDRES |
| description | PROBLEM TO BE SOLVED: To provide hypoallergenic chimeric proteins belonging to the lipid transfer family of Parietaria judaica for use in allergy treatment.SOLUTION: The invention relates to recombinant DNA molecules encoding chimeric polypeptide of various allergens of Parietaria judaica usable for prevention and treatment of allergies, in particular pollen allergy. Specifically described is a chimeric polypeptide comprising fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics. Also described is a method for preparing these recombinant polypeptides in a heterologous expression system. An efficient method for purifying the chimeric proteins is also described.SELECTED DRAWING: Figure 1
【課題】アレルギーの治療に用いるカベイラクサの脂質輸送ファミリーに属する低アレルギー誘発性のキメラタンパク質。【解決手段】本発明は、アレルギー、特に花粉症の予防及び治療に用いることができるカベイラクサの様々なアレルゲンのキメラポリペプチドをコードする組み換えＤＮＡ分子に関する。具体的には、低アレルギー誘発性の特性があるアレルゲンＰａｒ ｊ １及びＰａｒ ｊ ２の断片から構成されたキメラポリペプチドが記載される。異種発現系でこれらの組み換えポリペプチドを製造する方法も記載されている。キメラタンパク質を精製するのに有効な方法も記載されている。【選択図】図１ |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_JP2016104796A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JP2016104796A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_JP2016104796A3</originalsourceid><addsrcrecordid>eNqNjbEKwjAURbs4iPoPD3ehVak4PtOX9JU0CWk6dCpF4iRaqPj9FvQDXO49wz3cZfIuO2dRa_KKDAsQJdfkZ3DeBmLTwIW0NYqNgmBBs-MCgkfTSPIgsWbdgZXg0DOFORCqtkAWCNJ6aBsCNvA96GaRMNRkwjpZ3Ib7FDe_XiVbSUGUuzg--ziNwzU-4quv3D7N8iw9ns45Hv4afQCnjznv</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>HYPOALLERGENIC CHIMERIC PROTEINS BELONGING TO LIPID TRANSFER FAMILY OF PARIETARIA JUDAICA FOR USE IN ALLERGY TREATMENT</title><source>esp@cenet</source><creator>MARTINEZ GARATE ALBERTO ; GONZALES RIOJA ROBERTO ; ASTURIAS ORTEGA JUAN ANDRES</creator><creatorcontrib>MARTINEZ GARATE ALBERTO ; GONZALES RIOJA ROBERTO ; ASTURIAS ORTEGA JUAN ANDRES</creatorcontrib><description>PROBLEM TO BE SOLVED: To provide hypoallergenic chimeric proteins belonging to the lipid transfer family of Parietaria judaica for use in allergy treatment.SOLUTION: The invention relates to recombinant DNA molecules encoding chimeric polypeptide of various allergens of Parietaria judaica usable for prevention and treatment of allergies, in particular pollen allergy. Specifically described is a chimeric polypeptide comprising fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics. Also described is a method for preparing these recombinant polypeptides in a heterologous expression system. An efficient method for purifying the chimeric proteins is also described.SELECTED DRAWING: Figure 1
【課題】アレルギーの治療に用いるカベイラクサの脂質輸送ファミリーに属する低アレルギー誘発性のキメラタンパク質。【解決手段】本発明は、アレルギー、特に花粉症の予防及び治療に用いることができるカベイラクサの様々なアレルゲンのキメラポリペプチドをコードする組み換えＤＮＡ分子に関する。具体的には、低アレルギー誘発性の特性があるアレルゲンＰａｒ ｊ １及びＰａｒ ｊ ２の断片から構成されたキメラポリペプチドが記載される。異種発現系でこれらの組み換えポリペプチドを製造する方法も記載されている。キメラタンパク質を精製するのに有効な方法も記載されている。【選択図】図１</description><language>eng ; jpn</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160609&DB=EPODOC&CC=JP&NR=2016104796A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160609&DB=EPODOC&CC=JP&NR=2016104796A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MARTINEZ GARATE ALBERTO</creatorcontrib><creatorcontrib>GONZALES RIOJA ROBERTO</creatorcontrib><creatorcontrib>ASTURIAS ORTEGA JUAN ANDRES</creatorcontrib><title>HYPOALLERGENIC CHIMERIC PROTEINS BELONGING TO LIPID TRANSFER FAMILY OF PARIETARIA JUDAICA FOR USE IN ALLERGY TREATMENT</title><description>PROBLEM TO BE SOLVED: To provide hypoallergenic chimeric proteins belonging to the lipid transfer family of Parietaria judaica for use in allergy treatment.SOLUTION: The invention relates to recombinant DNA molecules encoding chimeric polypeptide of various allergens of Parietaria judaica usable for prevention and treatment of allergies, in particular pollen allergy. Specifically described is a chimeric polypeptide comprising fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics. Also described is a method for preparing these recombinant polypeptides in a heterologous expression system. An efficient method for purifying the chimeric proteins is also described.SELECTED DRAWING: Figure 1
【課題】アレルギーの治療に用いるカベイラクサの脂質輸送ファミリーに属する低アレルギー誘発性のキメラタンパク質。【解決手段】本発明は、アレルギー、特に花粉症の予防及び治療に用いることができるカベイラクサの様々なアレルゲンのキメラポリペプチドをコードする組み換えＤＮＡ分子に関する。具体的には、低アレルギー誘発性の特性があるアレルゲンＰａｒ ｊ １及びＰａｒ ｊ ２の断片から構成されたキメラポリペプチドが記載される。異種発現系でこれらの組み換えポリペプチドを製造する方法も記載されている。キメラタンパク質を精製するのに有効な方法も記載されている。【選択図】図１</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjbEKwjAURbs4iPoPD3ehVak4PtOX9JU0CWk6dCpF4iRaqPj9FvQDXO49wz3cZfIuO2dRa_KKDAsQJdfkZ3DeBmLTwIW0NYqNgmBBs-MCgkfTSPIgsWbdgZXg0DOFORCqtkAWCNJ6aBsCNvA96GaRMNRkwjpZ3Ib7FDe_XiVbSUGUuzg--ziNwzU-4quv3D7N8iw9ns45Hv4afQCnjznv</recordid><startdate>20160609</startdate><enddate>20160609</enddate><creator>MARTINEZ GARATE ALBERTO</creator><creator>GONZALES RIOJA ROBERTO</creator><creator>ASTURIAS ORTEGA JUAN ANDRES</creator><scope>EVB</scope></search><sort><creationdate>20160609</creationdate><title>HYPOALLERGENIC CHIMERIC PROTEINS BELONGING TO LIPID TRANSFER FAMILY OF PARIETARIA JUDAICA FOR USE IN ALLERGY TREATMENT</title><author>MARTINEZ GARATE ALBERTO ; GONZALES RIOJA ROBERTO ; ASTURIAS ORTEGA JUAN ANDRES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2016104796A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2016</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>MARTINEZ GARATE ALBERTO</creatorcontrib><creatorcontrib>GONZALES RIOJA ROBERTO</creatorcontrib><creatorcontrib>ASTURIAS ORTEGA JUAN ANDRES</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MARTINEZ GARATE ALBERTO</au><au>GONZALES RIOJA ROBERTO</au><au>ASTURIAS ORTEGA JUAN ANDRES</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HYPOALLERGENIC CHIMERIC PROTEINS BELONGING TO LIPID TRANSFER FAMILY OF PARIETARIA JUDAICA FOR USE IN ALLERGY TREATMENT</title><date>2016-06-09</date><risdate>2016</risdate><abstract>PROBLEM TO BE SOLVED: To provide hypoallergenic chimeric proteins belonging to the lipid transfer family of Parietaria judaica for use in allergy treatment.SOLUTION: The invention relates to recombinant DNA molecules encoding chimeric polypeptide of various allergens of Parietaria judaica usable for prevention and treatment of allergies, in particular pollen allergy. Specifically described is a chimeric polypeptide comprising fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics. Also described is a method for preparing these recombinant polypeptides in a heterologous expression system. An efficient method for purifying the chimeric proteins is also described.SELECTED DRAWING: Figure 1
【課題】アレルギーの治療に用いるカベイラクサの脂質輸送ファミリーに属する低アレルギー誘発性のキメラタンパク質。【解決手段】本発明は、アレルギー、特に花粉症の予防及び治療に用いることができるカベイラクサの様々なアレルゲンのキメラポリペプチドをコードする組み換えＤＮＡ分子に関する。具体的には、低アレルギー誘発性の特性があるアレルゲンＰａｒ ｊ １及びＰａｒ ｊ ２の断片から構成されたキメラポリペプチドが記載される。異種発現系でこれらの組み換えポリペプチドを製造する方法も記載されている。キメラタンパク質を精製するのに有効な方法も記載されている。【選択図】図１</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | HYPOALLERGENIC CHIMERIC PROTEINS BELONGING TO LIPID TRANSFER FAMILY OF PARIETARIA JUDAICA FOR USE IN ALLERGY TREATMENT |
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