HYPOALLERGENIC CHIMERIC PROTEINS BELONGING TO LIPID TRANSFER FAMILY OF PARIETARIA JUDAICA FOR USE IN ALLERGY TREATMENT

PROBLEM TO BE SOLVED: To provide hypoallergenic chimeric proteins belonging to the lipid transfer family of Parietaria judaica for use in allergy treatment.SOLUTION: The invention relates to recombinant DNA molecules encoding chimeric polypeptide of various allergens of Parietaria judaica usable for...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	MARTINEZ GARATE ALBERTO, GONZALES RIOJA ROBERTO, ASTURIAS ORTEGA JUAN ANDRES
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide hypoallergenic chimeric proteins belonging to the lipid transfer family of Parietaria judaica for use in allergy treatment.SOLUTION: The invention relates to recombinant DNA molecules encoding chimeric polypeptide of various allergens of Parietaria judaica usable for prevention and treatment of allergies, in particular pollen allergy. Specifically described is a chimeric polypeptide comprising fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics. Also described is a method for preparing these recombinant polypeptides in a heterologous expression system. An efficient method for purifying the chimeric proteins is also described.SELECTED DRAWING: Figure 1 【課題】アレルギーの治療に用いるカベイラクサの脂質輸送ファミリーに属する低アレルギー誘発性のキメラタンパク質。【解決手段】本発明は、アレルギー、特に花粉症の予防及び治療に用いることができるカベイラクサの様々なアレルゲンのキメラポリペプチドをコードする組み換えＤＮＡ分子に関する。具体的には、低アレルギー誘発性の特性があるアレルゲンＰａｒｊ１及びＰａｒｊ２の断片から構成されたキメラポリペプチドが記載される。異種発現系でこれらの組み換えポリペプチドを製造する方法も記載されている。キメラタンパク質を精製するのに有効な方法も記載されている。【選択図】図１