METHOD FOR INDUCING TRIF-BIAS

PROBLEM TO BE SOLVED: To provide a synthetic lipid A mimetic, particularly the APG compound CRX547, to induce TRIF-biased signaling through the TLR4 receptor complex.SOLUTION: The invention provides a pharmaceutical composition for reducing levels of MyD88-dependent cytokines relative to the MyD88-d...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	MELINDA M HUTTON, LAURIE A MINNS, JAY T EVANS, WILLIAM S BOWEN, DAVID A JOHNSON
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a synthetic lipid A mimetic, particularly the APG compound CRX547, to induce TRIF-biased signaling through the TLR4 receptor complex.SOLUTION: The invention provides a pharmaceutical composition for reducing levels of MyD88-dependent cytokines relative to the MyD88-dependent cytokines induced when a composition containing a lipid A mimetic that is not CRX547 is administered to a human. The pharmaceutical composition contains CRX547 and a lipid A mimetic that is not CRX547.SELECTED DRAWING: None 【課題】ＴＬＲ４受容体複合体を介してＴＲＩＦバイアスシグナルを誘発するための合成リピッドＡ模倣物、特にＡＰＧ化合物ＣＲＸ５４７組成物。【解決手段】ＣＲＸ５４７ではないリピッドＡ模倣物を含む組成物をヒトに投与した場合に誘発されるＭｙＤ８８依存的サイトカインのレベルと比べて、ＭｙＤ８８依存的サイトカインのレベルを減少させるための医薬組成物であって、該医薬組成物がＣＲＸ５４７ではないリピッドＡ模倣物およびＣＲＸ５４７を含む、医薬組成物。【選択図】なし