HALOARYL-SUBSTITUTED AMINOPURINE, COMPOSITION THEREOF AND TREATING METHOD THEREWITH

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition comprising a novel aminopurine that inhibits a kinase pathway (in particular, JNK protein).SOLUTION: Provided is a pharmaceutical composition comprising an aminopurine derivative represented by Formula (I).EFFECT: The aminopurine compound is capable of inhibiting a kinase pathway (in particular, JNK protein), and is effective in treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, inflammation conditions, macular degeneration, ischemia reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a disease or condition treatable or preventable by inhibition of a kinase pathway, in particular, the JNK pathway.SELECTED DRAWING: None 【課題】キナーゼ経路（特に、ＪＮＫタンパク質）阻害作用を有する新規なアミノプリンを含む医薬組成物の提供。【解決手段】式（Ｉ）で表されるアミノプリン誘導体を含む医薬組成物。【効果】前記アミノプリン化合物は、キナーゼ経路（特に、ＪＮＫタンパク質）阻害作用を有し、癌、循環器疾患、腎疾患、自己免疫状態、炎症状態、黄斑変性、虚血再灌流傷害、疼痛及び関連する症候群、疾病に関連する消耗、アスベストに関連する状態、肺高血圧症、又はキナーゼ（特に、JNK）経路の阻害により治療又は予防予防に有効である。【選択図】なし