CXCR4 RECEPTOR ANTAGONISTS

PROBLEM TO BE SOLVED: To provide a novel compound having CXCR4 antagonist action and useful for the treatment of diseases such as cancer, cancer metastasis, HIV/AIDS, neuropathy, HIV related neuropathy, brain inflammation, diabetic retinopathy, age-related macular degeneration, and retinal neovascularization.SOLUTION: The present invention provides a compound of formula (I), where Ris a heterocycle-carbamoyl group such as pyridine-4-ylcarbamoyl; Ris an optionally substituted heterocyclic group such as 1-isopropylpiperidine-4-yl; X is a 5 or 6 membered aromatic heterocyclic diyl group such as pyridine-2,6-diyl; Y is a heterocyclic diyl group such as homopiperazine-1,4-diyl.SELECTED DRAWING: None 【課題】ＣＸＣＲ４アンタゴニスト作用を有し、癌、癌の転移、ＨＩＶ／ＡＩＤＳ、神経障害、ＨＩＶ関連神経障害、脳炎症、糖尿病性網膜症、加齢黄斑変性、網膜血管新生等の疾患の治療に有用な新規化合物の提供。【解決手段】下記式（Ｉ）で表される化合物。（Ｒ１はピリジン−４−イルカルバモイル等の複素環−カルバモイル基；Ｒ２は１−イソプロピルピペリジン−４−イル等の置換可複素環基；Ｘはピリジン−２，６−ジイル等の５又は６員の芳香複素環ジイル基；Ｙはホモピペラジン−１，４−ジイル等の複素環ジイル基等。）【選択図】なし