HUMANIZED ANTIBODIES SPECIFIC TO PROTOFIBRILLAR FORM OF -AMYLOID PEPTIDE
PROBLEM TO BE SOLVED: To provide humanized antibodies specific to the protofibrillar form of the -amyloid peptide, and the use of the antibodies in the field of Alzheimer's disease.SOLUTION: The present invention relates to an antibody which binds to the A- peptides aggregated into senile plaqu...
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| creator | BLANCHE FRANCIS SOUAD NAIMI NICOLAS BAURIN VINCENT MIKOL DUCHESNE MARC SHI YI BEATRICE CAMERON LAURENT PRADIER |
| description | PROBLEM TO BE SOLVED: To provide humanized antibodies specific to the protofibrillar form of the -amyloid peptide, and the use of the antibodies in the field of Alzheimer's disease.SOLUTION: The present invention relates to an antibody which binds to the A- peptides aggregated into senile plaques and not to the diffuse deposits of A- peptides and whose affinity for the protofibrillar form of the peptide A- is at least 100 times greater than its affinity for the other forms of this peptide. The invention further relates to a recombinant vector comprising a nucleic acid encoding the antibody, and a host cell containing the vector.SELECTED DRAWING: Figure 4A
【課題】β−アミロイドペプチドのプロトフィブリル体に特異的なヒト化抗体、および該抗体のアルツハイマー病の分野における使用の提供。【解決手段】抗体が、老人斑中で凝集したＡ−βペプチドには結合するが、Ａβペプチドのびまん性沈着物には結合しないことを特徴とし、該抗体のペプチドＡβのプロトフィブリル体に対する親和性が、該抗体のこのペプチドの他の形態に対する親和性よりも少なくとも１００倍の大きさであることを特徴とする抗体。更に、該抗体をコードする核酸を含む、組換えベクター、及び該ベクターを含有する宿主細胞に関する。【選択図】図４Ａ |
| format | Patent |
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【課題】β−アミロイドペプチドのプロトフィブリル体に特異的なヒト化抗体、および該抗体のアルツハイマー病の分野における使用の提供。【解決手段】抗体が、老人斑中で凝集したＡ−βペプチドには結合するが、Ａβペプチドのびまん性沈着物には結合しないことを特徴とし、該抗体のペプチドＡβのプロトフィブリル体に対する親和性が、該抗体のこのペプチドの他の形態に対する親和性よりも少なくとも１００倍の大きさであることを特徴とする抗体。更に、該抗体をコードする核酸を含む、組換えベクター、及び該ベクターを含有する宿主細胞に関する。【選択図】図４Ａ</description><language>eng ; jpn</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160303&DB=EPODOC&CC=JP&NR=2016028591A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160303&DB=EPODOC&CC=JP&NR=2016028591A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BLANCHE FRANCIS</creatorcontrib><creatorcontrib>SOUAD NAIMI</creatorcontrib><creatorcontrib>NICOLAS BAURIN</creatorcontrib><creatorcontrib>VINCENT MIKOL</creatorcontrib><creatorcontrib>DUCHESNE MARC</creatorcontrib><creatorcontrib>SHI YI</creatorcontrib><creatorcontrib>BEATRICE CAMERON</creatorcontrib><creatorcontrib>LAURENT PRADIER</creatorcontrib><title>HUMANIZED ANTIBODIES SPECIFIC TO PROTOFIBRILLAR FORM OF -AMYLOID PEPTIDE</title><description>PROBLEM TO BE SOLVED: To provide humanized antibodies specific to the protofibrillar form of the -amyloid peptide, and the use of the antibodies in the field of Alzheimer's disease.SOLUTION: The present invention relates to an antibody which binds to the A- peptides aggregated into senile plaques and not to the diffuse deposits of A- peptides and whose affinity for the protofibrillar form of the peptide A- is at least 100 times greater than its affinity for the other forms of this peptide. The invention further relates to a recombinant vector comprising a nucleic acid encoding the antibody, and a host cell containing the vector.SELECTED DRAWING: Figure 4A
【課題】β−アミロイドペプチドのプロトフィブリル体に特異的なヒト化抗体、および該抗体のアルツハイマー病の分野における使用の提供。【解決手段】抗体が、老人斑中で凝集したＡ−βペプチドには結合するが、Ａβペプチドのびまん性沈着物には結合しないことを特徴とし、該抗体のペプチドＡβのプロトフィブリル体に対する親和性が、該抗体のこのペプチドの他の形態に対する親和性よりも少なくとも１００倍の大きさであることを特徴とする抗体。更に、該抗体をコードする核酸を含む、組換えベクター、及び該ベクターを含有する宿主細胞に関する。【選択図】図４Ａ</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPDwCPV19POMcnVRcPQL8XTyd_F0DVYIDnB19nTzdFYI8VcICPIP8XfzdAry9PFxDFJw8w_yVfB3U9B19I308fd0UQhwDQjxdHHlYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxXgFGBoZmBkYWppaGjsZEKQIAZtktUg</recordid><startdate>20160303</startdate><enddate>20160303</enddate><creator>BLANCHE FRANCIS</creator><creator>SOUAD NAIMI</creator><creator>NICOLAS BAURIN</creator><creator>VINCENT MIKOL</creator><creator>DUCHESNE MARC</creator><creator>SHI YI</creator><creator>BEATRICE CAMERON</creator><creator>LAURENT PRADIER</creator><scope>EVB</scope></search><sort><creationdate>20160303</creationdate><title>HUMANIZED ANTIBODIES SPECIFIC TO PROTOFIBRILLAR FORM OF -AMYLOID PEPTIDE</title><author>BLANCHE FRANCIS ; SOUAD NAIMI ; NICOLAS BAURIN ; VINCENT MIKOL ; DUCHESNE MARC ; SHI YI ; BEATRICE CAMERON ; LAURENT PRADIER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2016028591A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2016</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>BLANCHE FRANCIS</creatorcontrib><creatorcontrib>SOUAD NAIMI</creatorcontrib><creatorcontrib>NICOLAS BAURIN</creatorcontrib><creatorcontrib>VINCENT MIKOL</creatorcontrib><creatorcontrib>DUCHESNE MARC</creatorcontrib><creatorcontrib>SHI YI</creatorcontrib><creatorcontrib>BEATRICE CAMERON</creatorcontrib><creatorcontrib>LAURENT PRADIER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BLANCHE FRANCIS</au><au>SOUAD NAIMI</au><au>NICOLAS BAURIN</au><au>VINCENT MIKOL</au><au>DUCHESNE MARC</au><au>SHI YI</au><au>BEATRICE CAMERON</au><au>LAURENT PRADIER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HUMANIZED ANTIBODIES SPECIFIC TO PROTOFIBRILLAR FORM OF -AMYLOID PEPTIDE</title><date>2016-03-03</date><risdate>2016</risdate><abstract>PROBLEM TO BE SOLVED: To provide humanized antibodies specific to the protofibrillar form of the -amyloid peptide, and the use of the antibodies in the field of Alzheimer's disease.SOLUTION: The present invention relates to an antibody which binds to the A- peptides aggregated into senile plaques and not to the diffuse deposits of A- peptides and whose affinity for the protofibrillar form of the peptide A- is at least 100 times greater than its affinity for the other forms of this peptide. The invention further relates to a recombinant vector comprising a nucleic acid encoding the antibody, and a host cell containing the vector.SELECTED DRAWING: Figure 4A
【課題】β−アミロイドペプチドのプロトフィブリル体に特異的なヒト化抗体、および該抗体のアルツハイマー病の分野における使用の提供。【解決手段】抗体が、老人斑中で凝集したＡ−βペプチドには結合するが、Ａβペプチドのびまん性沈着物には結合しないことを特徴とし、該抗体のペプチドＡβのプロトフィブリル体に対する親和性が、該抗体のこのペプチドの他の形態に対する親和性よりも少なくとも１００倍の大きさであることを特徴とする抗体。更に、該抗体をコードする核酸を含む、組換えベクター、及び該ベクターを含有する宿主細胞に関する。【選択図】図４Ａ</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | HUMANIZED ANTIBODIES SPECIFIC TO PROTOFIBRILLAR FORM OF -AMYLOID PEPTIDE |
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