PYRAZOLE DERIVATIVE MODULATOR OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL AND METHOD FOR TREATMENT OF NON-SMALL CELL LUNG CANCER

PROBLEM TO BE SOLVED: To provide novel calcium release-activated calcium (CRAC) channel inhibitors.SOLUTION: The present invention provides a compound represented by the following formula, or a tautomer, a prodrug, an N-oxide, a pharmacologically acceptable ester or a pharmacologically acceptable salt thereof (where, ring Hy is an optionally substituted, 1,2-diazole ring; ring Ar is a benzene ring, a pyridine ring or the like; L1 and L2 together represent -NH-C(=O)-, -C(=O)NH- or the like; A is not present or represents an alkylene group or the like; Cy is a bicyclic ring selected from a substituted/unsubstituted cycloalkyl group, a substituted/unsubstituted heterocyclyl, a substituted/unsubstituted aryl and a substituted/unsubstituted heteroaryl).SELECTED DRAWING: None 【課題】新規なカルシウム放出依存性カルシウム（ＣＲＡＣ）チャネル阻害剤の提供。【解決手段】式で表される化合物、又はその互変異性体、プロドラッグ、Ｎ−オキシド、薬学的に許容されるエステル若しくは薬学的に許容される塩。（環Ｈｙは任意に置換された、１，２−ジアゾール環；環Ａｒはベンゼン環、ピリジン環等；Ｌ１及びＬ２は一緒になって、−ＮＨ−Ｃ（＝Ｏ）−、−Ｃ（＝Ｏ）ＮＨ−等；Ａは存在しないか又はアルキレン基等；Ｃｙは置換／非置換のシクロアルキル基、置換／非置換のヘテロシクリル、置換／非置換のアリール又は置換／非置換のヘテロアリールの二環式環）【選択図】なし