NORTH AMERICAN PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VIRUS AND USES THEREOF

PROBLEM TO BE SOLVED: To provide vaccines against the porcine reproductive and respiratory syndrome virus (PRRS), and a diagnostic kit to distinguish between naturally infected and vaccinated animals.SOLUTION: The invention produces: polynucleotide molecules derived from infectious RNA molecules enc...

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Bibliographische Detailangaben
Hauptverfasser:	SLADE DAVID EWELL, JAY GREGORY CALVERT, WELCH SIAO-KUN WAN
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide vaccines against the porcine reproductive and respiratory syndrome virus (PRRS), and a diagnostic kit to distinguish between naturally infected and vaccinated animals.SOLUTION: The invention produces: polynucleotide molecules derived from infectious RNA molecules encoded onto a PRRS viral genome ORF1a genetically modified to elicit an effective immunoprotective response to a PRRS virus in porcine animals; polypeptides thereof; and transfected host cells.SELECTED DRAWING: Figure 5 【課題】ブタ繁殖・呼吸障害症候群ウイルス（ＰＲＲＳ）のワクチン、並びに天然に感染された及びワクチン接種された動物を識別するための診断キットの提供。【解決手段】ブタ動物においてＰＲＲＳウイルスに対する有効な免疫保護性反応を誘発するように遺伝子的に改変された、ＰＲＲＳウイルスゲノムＯＲＦ１ａ上にコードされる感染性ＲＮＡ分子由来のポリヌクレオチド分子、並びにそのポリペプチド、遺伝子導入された宿主細胞の作製。【選択図】図５