ANTI-TUMOR NECROSIS FACTOR-α HUMANIZED ANTIBODY

PROBLEM TO BE SOLVED: To provide an anti-tumor necrosis factor humanized monoclonal antibody; a nucleic acid sequence encoding this; a vector comprising the nucleic acid sequence; and a host cell thereof; and to provide a pharmaceutical composition comprising the humanized antibody and a use of the pharmaceutical composition in preparing a medicament to diagnose and treat hTNFα-related diseases.SOLUTION: The invention provides an anti-tumor necrosis factor humanized monoclonal antibody comprising a heavy chain having a specific amino acid sequence or an amino acid sequence maintaining at least 75% homologous to it; and a light chain having a specific amino acid sequence or an amino acid sequence maintaining at least 75% homologous to it. 【課題】抗腫瘍壊死因子ヒト化モノクローナル抗体、これをコードする核酸配列、前記核酸配列を含むベクター及びその宿主細胞の提供。又、該ヒト化抗体を含む医薬組成物及びhTNFα関連疾患の診断と治療のための医薬の製造における前記医薬組成物の用途の提供。【解決手段】特定のアミノ酸配列またはそれに対し少なくとも７５％の相同性を保持するアミノ酸配列を有する重鎖と、特定のアミノ酸配列またはそれに対し少なくとも７５％の相同性を保持するアミノ酸配列を有する軽鎖と、を含む抗腫瘍壊死因子ヒト化モノクローナル抗体。【選択図】なし