INSULIN RESISTANCE IMPROVING AGENT

PROBLEM TO BE SOLVED: To provide formulations which can safely and effectively improve insulin resistance leading to development of diseases including a type 2 diabetes mellitus or metabolic syndrome.SOLUTION: The invention relates to a composition containing press residues of apple fruits and rosem...

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Bibliographische Detailangaben
1. Verfasser:	YAMAHARA JOJI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide formulations which can safely and effectively improve insulin resistance leading to development of diseases including a type 2 diabetes mellitus or metabolic syndrome.SOLUTION: The invention relates to a composition containing press residues of apple fruits and rosemary extract. The invention relates to an insulin resistance improving agent, in which rosemary leaf extract is preferable as a rosemary extract, and preferably it is extracted using C1-4 alcohol as an extracting solvent. The composition containing 5 to 15-fold press residues of apple fruits at a mass ratio to the rosemary extract is administered at doses of 10-50 mg/kg per day. 【課題】２型糖尿病やメタボリック・シンドロームを始めとする疾患の発症につながるインスリン抵抗性を、安全かつ効果的に改善できる製剤の提供。【解決手段】リンゴ果実圧搾残渣及びローズマリー抽出物を含有する組成物。ローズマリー抽出物としては、ローズマリーの葉の抽出物が好ましく、また抽出溶媒としてＣ1-4アルコールを用いて抽出されたものが好ましいインスリン抵抗性改善剤。ローズマリー抽出物に対する質量比で５〜１５倍のリンゴ果実圧搾残渣を含む組成物を１日当り１０〜５０ｍｇ／ｋｇ投与するインスリン抵抗性改善剤。【選択図】なし