METHOD FOR TREATING LEUKEMIA AND CHRONIC MYELOPROLIFERATIVE DISEASES WITH ANTIBODIES TO EphA3

PROBLEM TO BE SOLVED: To provide a method for treating leukemias and chronic myeloproliferative diseases with antibodies to EphA3.SOLUTION: A method of killing myeloproliferative disorder cells that express EphA3 on the cell surface comprises a step of contacting the cells with an anti-EphA3 antibod...

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Hauptverfasser:	CHRISTOPHER R BEBBINGTON, GEOFFREY T YARRANTON, PALATH VARGHESE
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for treating leukemias and chronic myeloproliferative diseases with antibodies to EphA3.SOLUTION: A method of killing myeloproliferative disorder cells that express EphA3 on the cell surface comprises a step of contacting the cells with an anti-EphA3 antibody, where the antibody activates EphA3 and induces antibody- dependent cell-mediated cytotoxicity (ADCC). A treatment method comprises a step of administering a therapeutically effective amount of an anti-EphA3 antibody to a patient that has a myeloproliferative disorder and has myeloproliferative disorder cells that express EphA3 on the cell surface thereof. 【課題】ＥｐｈＡ３に対する抗体を用いた、白血病及び慢性骨髄増殖性疾患の治療方法の提供。【解決手段】細胞表面上にＥｐｈＡ３を発現する骨髄増殖性疾患細胞を殺傷する方法であって、該細胞を抗ＥｐｈＡ３抗体と接触させる段階を含み、該抗体がＥｐｈＡ３を活性化し、かつ抗体依存性細胞媒介性細胞傷害（ＡＤＣＣ）を誘導する方法。並びに、骨髄増殖性疾患を有し、かつ細胞表面上にＥｐｈＡ３を発現する骨髄増殖性疾患細胞を有する患者に治療有効量の抗ＥｐｈＡ３抗体を投与する段階を含む治療方法。【選択図】図２