AXL ANTIBODIES

PROBLEM TO BE SOLVED: To provide antibodies, particularly to monoclonal antibodies, which bind to the extracellular domain of the AXL receptor tyrosine kinase and which at least partially inhibit AXL activity.SOLUTION: Monoclonal antibodies which bind to the extracellular domain of AXL and which at...

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Hauptverfasser:	WIRZ PETER, JENS RUHE, JENS NIEWOEHNER, KERSTIN SELLE, THORE HETTMANN, MIKE ROTHE, ESTHER ZWICK-WALLASCH
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide antibodies, particularly to monoclonal antibodies, which bind to the extracellular domain of the AXL receptor tyrosine kinase and which at least partially inhibit AXL activity.SOLUTION: Monoclonal antibodies which bind to the extracellular domain of AXL and which at least partially inhibit AXL activity comprise a heavy chain amino acid sequence comprising CDRs which are (a) CDRH1 shown in a specific sequence, (b) CDRH2 shown in a specific sequence, and (c) CDRH3 shown in a specific sequence 18, and a light chain amino acid sequence comprising CDRs which are (d) CDRL1 shown in a specific sequence, (e) CDRL2 shown in a specific sequence, and (f) CDRL3 shown in a specific sequence. 【課題】抗体、特にAXL受容体型チロシンキナーゼの細胞外ドメインと結合し、AXL活性を少なくとも部分的に阻害するモノクローナル抗体の提供。【解決手段】AXLの細胞外ドメインと結合し、AXL活性を少なくとも部分的に阻害するモノクローナル抗体であって、(a)特定の配列に示すCDRH1、(b)特定の配列示すCDRH2、及び(c)特定の配列18に示すCDRH3であるCDRを含む重鎖アミノ酸配列、並びに(d)特定の配列に示すCDRL1、(e)特定の配列に示すCDRL2、および(f)特定の配列に示すCDRL3であるCDRを含む軽鎖アミノ酸配列を含む、モノクローナル抗体。【選択図】なし