GENETICALLY MODIFIED HUMAN UMBILICAL CORD PERIVASCULAR CELLS FOR PROPHYLAXIS AGAINST OR TREATMENT OF BIOLOGICAL OR CHEMICAL AGENTS

PROBLEM TO BE SOLVED: To provide methods of preventing or treating diseases or disorders caused by biological agents or chemical agents in a subject (e.g., a mammal, such as a human) by administering genetically modified human umbilical cord perivascular cells.SOLUTION: The present invention provide...

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Hauptverfasser:	JEFFREY DONALD TURNER, JANE ELIZABETH ENNIS, JOHN EDWARD DAVIES
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide methods of preventing or treating diseases or disorders caused by biological agents or chemical agents in a subject (e.g., a mammal, such as a human) by administering genetically modified human umbilical cord perivascular cells.SOLUTION: The present invention provides a method for protecting the subject against challenge from the biological or chemical agents, wherein the method comprises administering a human umbilical cord perivascular cell (HUCPVC) that has been genetically modified to increase the expression of an oligonucleotide or a polypeptide in the HUCPVC relative to a HUCPVC that has not been genetically modified, and the HUCPVC protects the subject from the biological or chemical agents. 【課題】遺伝子改変されたヒト臍帯血管周囲細胞を投与することによって、対象（例えば、ヒトなどの哺乳動物）中で生物学的作用物質又は化学的作用物質によって引き起こされる疾患又は障害を予防又は治療する方法の提供。【解決手段】生物学的又は化学的作用物質からの攻撃に対して対象を保護するための方法であって、遺伝子改変されていないヒト臍帯血管周囲細胞（ＨＵＣＰＶＣ）と比較して該ＨＵＣＰＶＣ中でのオリゴヌクレオチド又はポリペプチドの発現が増大するように遺伝子改変されたＨＵＣＰＶＣを対象に投与することを含み、該ＨＵＣＰＶＣが前記生物学的又は化学的作用物質から該対象を保護する方法。【選択図】なし